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. 2023 Mar 16;23(2):235-247.
doi: 10.17305/bjbms.2022.8175.

Metabolic aspects of surgical subcutaneous fat removal: An umbrella review and implications for future research

Saif Badran  1 , Suhail A Doi  2 , Moustapha Hamdi  3 , Atalla Hammouda  4 , Sara Alharami  4 , Justin Clark  5 , Omran A H Musa  2 , Abdul-Badi Abou-Samra  6 , Abdella M Habib  7
Affiliations

Metabolic aspects of surgical subcutaneous fat removal: An umbrella review and implications for future research

Saif Badran et al. Biomol Biomed. .

Abstract

Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve physical appearance. The need for SSFR is further exacerbated because of the global rise in the number of bariatric surgeries, which is currently the single most durable intervention for mitigating obesity. Fat tissue is now recognized as a vital endocrine organ that produces several bioactive proteins. Thus, SSFR-mediated weight (fat) loss can potentially have significant metabolic effects; however, currently, there is no consensus on this issue. This review focuses on the metabolic sequelae after SSFR interventions for dealing with cosmetic body appearance. Data was extracted from existing systematic reviews and the diversity of possible metabolic changes after SSFR are reported along with gaps in the knowledge and future directions for research and practice. We conclude that there is a potential for metabolic sequelae after SSFR interventions and their clinical implications for the safety of the procedures as well as for our understanding of subcutaneous adipose tissue biology and insulin resistance are discussed.

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Conflict of interest statement

Conflict of interest: The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.
PRISMA flow diagram of the study selection process.
Figure S1.
Figure S1.
Search strings.
Figure S2.
Figure S2.
Quality assessment of the four syntheses. The thick boxes indicate presence of the quality safeguard and the thin boxes indicate they are partially present. Missing numbers indicate the safeguard was missing.
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