Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 16;23(2):235-247.
doi: 10.17305/bjbms.2022.8175.

Metabolic aspects of surgical subcutaneous fat removal: An umbrella review and implications for future research

Saif Badran  1 , Suhail A Doi  2 , Moustapha Hamdi  3 , Atalla Hammouda  4 , Sara Alharami  4 , Justin Clark  5 , Omran A H Musa  2 , Abdul-Badi Abou-Samra  6 , Abdella M Habib  7
Affiliations

Metabolic aspects of surgical subcutaneous fat removal: An umbrella review and implications for future research

Saif Badran et al. Biomol Biomed. .

Abstract

Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve physical appearance. The need for SSFR is further exacerbated because of the global rise in the number of bariatric surgeries, which is currently the single most durable intervention for mitigating obesity. Fat tissue is now recognized as a vital endocrine organ that produces several bioactive proteins. Thus, SSFR-mediated weight (fat) loss can potentially have significant metabolic effects; however, currently, there is no consensus on this issue. This review focuses on the metabolic sequelae after SSFR interventions for dealing with cosmetic body appearance. Data was extracted from existing systematic reviews and the diversity of possible metabolic changes after SSFR are reported along with gaps in the knowledge and future directions for research and practice. We conclude that there is a potential for metabolic sequelae after SSFR interventions and their clinical implications for the safety of the procedures as well as for our understanding of subcutaneous adipose tissue biology and insulin resistance are discussed.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.
PRISMA flow diagram of the study selection process.
Figure S1.
Figure S1.
Search strings.
Figure S2.
Figure S2.
Quality assessment of the four syntheses. The thick boxes indicate presence of the quality safeguard and the thin boxes indicate they are partially present. Missing numbers indicate the safeguard was missing.
See this image and copyright information in PMC

References

    1. Obesity and overweight [Internet]. [cited 2021 Mar 14]. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
    1. Cao H. Adipocytokines in obesity and metabolic disease. J Endocrinol. 2014 Feb 1;220(2):T47–59. https://doi.org/10.1530/JOE-13-0339. - PMC - PubMed
    1. Bergé J-P, Barnathan G. Fatty acids from lipids of marine organisms: molecular biodiversity, roles as biomarkers, biologically active compounds, and economical aspects. Adv Biochem Eng Biotechnol. 2005 Aug 24;96:49–125. https://doi.org/10.1007/b135782. - PubMed
    1. Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. Int J Mol Sci. 2017 Jun 21;18(6):1321. https://doi.org/10.3390/ijms18061321. - PMC - PubMed
    1. Frayn KN. Adipose tissue and the insulin resistance syndrome. Proc Nutr Soc. 2001 Aug;60(3):375–80. https://doi.org/10.1079/pns200195. - PubMed

Publication types