Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan-Dec:29:10732748221130964.
doi: 10.1177/10732748221130964.

Pilot Study on the Impact of a Home-Based Exercise Program on Inflammatory Cytokines and Quality of Life in Men with Prostate Cancer Under Active Surveillance

Crisann Moon  1 , Amber M Gallegos  1 , Bilal Sheikh  1 , Pratap Kumar  2   3 , Michael Liss  2   3 , Darpan I Patel  1   3   4
Affiliations

Pilot Study on the Impact of a Home-Based Exercise Program on Inflammatory Cytokines and Quality of Life in Men with Prostate Cancer Under Active Surveillance

Crisann Moon et al. Cancer Control. 2022 Jan-Dec.

Abstract

Objectives: This study aimed to demonstrate potential translation of pre-clinical studies to a home-based exercise intervention in mediating inflammatory cytokine markers and tumor progression in men under active surveillance for prostate cancer.

Methods: A 2-arm randomized control parallel group design was used. The exercise intervention consisted of 24 weeks of an aerobic and resistance home-based exercise program and results were compared to a waitlist control group. Data were collected at baseline and end of study for eotaxin, interferon-γ (INF-γ), interleukin-12 (IL-12), interleukin-1α (IL-1α), interleukin-5 (IL-5), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF), distanced walked during a 6-minute walk test (6MWT), body mass index, and health-related quality of life.

Results: Non-significant decreases were observed in all biomarkers, especially VEGF (pre: 125.16 ± 198.66, post: 80.29 ± 124.30, P = .06) and INF-γ (pre: 152.88 ± 312.71, post: 118.93 ± 158.79, P = .08), in the intervention group; only IL- α (pre: 332.15 ± 656.77, post: 255.12 ± 502.09, P = .20) decreased in the control group while all other biomarkers increased from baseline to end of study. A non-significant increase in 6MWT distance was observed in the intervention group, while a decrease was seen in the control group. Significant decreases in physical function, emotional wellbeing, and total composite scale on the FACIT-F were observed in the intervention group, possibly due to the isolation restrictions of COVID-19. Physical function on the SF-36 significantly increased in the control group.

Conclusions: Future studies with powered samples are needed to confirm the trends observed for inflammatory biomarkers and functional fitness.

Keywords: active surveillance; biomarker; exercise; prostate cancer; quality of life.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Study flow diagram.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. National Cancer Institute . Surveillance, Epidemiology, and End Results Program (SEER) cancer stat facts: Prostate cancer; 2021.
    1. Keough JWL, MacLeod RD. Body composition, physical fitness, functional performance, quality of life, and fatigue benefits of exercise for prostate cancer patients: A systematic review. J Pain Symptom Manag. 2012;43(1):96-110. doi:10.1016/j.jpainsymman.2011.03.006. - DOI - PubMed
    1. Auffenberg G, Lane BR, Miller DC. Practice- vs physician-level variation in use of active surveillance for men with low-risk prostate cancer. JAMA Surgery. 2017;152(10):978-980. doi:10.1001/jamasurg.2017.1586. - DOI - PMC - PubMed
    1. Timilshina N, Komisarenko M, Martin LJ, et al. Factor associated with discontinuation of active surveillance among men with low-risk prostate cancer: A population-based study. J Urol. 2021;206(4):903-913. doi:10.1097/JU.0000000000001903. - DOI - PubMed
    1. Yang J, Hong-Fei W, Qian L-X, et al. Increased expressions of vascular endothelial growth factor (VEGF), VEGF-C and VEGF receptor-3 in prostate cancer tissue are associated with tumor progression. Asian J Androl. 2006;8:169-175. doi:10.1111/j.1745-7262.2006.00120.x. - DOI - PubMed