Dietary tea seed saponin combined with aerobic exercise attenuated lipid metabolism and oxidative stress in mice fed a high-fat diet (HFD)

doi:10.1111/jfbc.14461

. 2022 Dec;46(12):e14461.

doi: 10.1111/jfbc.14461. Epub 2022 Oct 6.

Dietary tea seed saponin combined with aerobic exercise attenuated lipid metabolism and oxidative stress in mice fed a high-fat diet (HFD)

Wenjing Cao^{1

2}, Keying Wang¹, Chanhua Liang^{1

3}, Yanming Su¹, Shuang Liu¹, Jiali Li¹, Huishan Qing¹, Zhen Zeng^{1

4}, Ling Dai⁵, Jia-Le Song^{1

6

7

8}

Affiliations

¹ Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, China.
² School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
³ School of Public Health, Huazhong University of Science and Technology Tongji Medical College, Wuhan, China.
⁴ Department of Pediatrics and Maternal and Child Health, Xiangya College of Public Health, Central South University, Changsha, China.
⁵ Center of Mental Health Education and Counseling, Guilin Medical University, Guilin, China.
⁶ Department of Clinical Nutrition and Obstetrics, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.
⁷ Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin, China.
⁸ Guangxi Key Laboratory of Environmental Exposureomics and Entire Lifecycle Health, Guilin Medical University, Guilin, China.

PMID: 36200661
DOI: 10.1111/jfbc.14461

Dietary tea seed saponin combined with aerobic exercise attenuated lipid metabolism and oxidative stress in mice fed a high-fat diet (HFD)

Wenjing Cao et al. J Food Biochem. 2022 Dec.

. 2022 Dec;46(12):e14461.

doi: 10.1111/jfbc.14461. Epub 2022 Oct 6.

Authors

Wenjing Cao^{1

2}, Keying Wang¹, Chanhua Liang^{1

3}, Yanming Su¹, Shuang Liu¹, Jiali Li¹, Huishan Qing¹, Zhen Zeng^{1

4}, Ling Dai⁵, Jia-Le Song^{1

6

7

8}

Affiliations

¹ Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, China.
² School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
³ School of Public Health, Huazhong University of Science and Technology Tongji Medical College, Wuhan, China.
⁴ Department of Pediatrics and Maternal and Child Health, Xiangya College of Public Health, Central South University, Changsha, China.
⁵ Center of Mental Health Education and Counseling, Guilin Medical University, Guilin, China.
⁶ Department of Clinical Nutrition and Obstetrics, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.
⁷ Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin, China.
⁸ Guangxi Key Laboratory of Environmental Exposureomics and Entire Lifecycle Health, Guilin Medical University, Guilin, China.

PMID: 36200661
DOI: 10.1111/jfbc.14461

Abstract

Tea seed saponins (TSS) are oleanolane-type pentacyclic triterpenoid saponin mixtures with various pharmacological effects. We aimed to explore the effects of a total of 4 weeks intragastric administration of TSS (140 mg/kg·day) combined with aerobic exercise (AE) on lipid metabolism and its associated oxidative stress in HFD-induced obese mice and to investigate the possible molecular mechanisms. TSS + AE intervention significantly reduced body weight and the adiposity index (including subcutaneous, epididymal, perirenal, and abdominal adipose) in obese mice; improved dyslipidemia by lowering serum TC, TG, and LDL-c levels; and increased HDL-c levels. TSS + AE intervention significantly improved hepatic steatosis by inhibiting lipogenetic Acc, Srebp1c, and Scd1 and upregulating lipolysis genes (Pgc1α, Pgc1β, Pparα, and Cpt1). TSS + AE intervention increased the hepatic protein expression of p-AMPK, SIRT1, and PGC-1α, as well as PPAR-γ and GLUT-4 in skeletal muscle compared with expression in the HFD group. In addition, TSS + AE also modulated oxidative stress in obese mice, which was indicated by the increased serum and liver levels of SOD, GSH, and T-AOC and decreased ROS and MDA levels. These results suggest that TSS + AE intervention can reduce fat accumulation and improve HFD-induced lipid metabolism disorders and oxidative stress. PRACTICAL APPLICATIONS: Obesity is a metabolic disease induced by excess nutritional intake and insufficient energy expenditure. Dietary modifications combined with aerobic exercise are currently an effective method for weight loss. Tea seed saponins (TSS) are a variety of biologically active oleanolane-type pentacyclic triterpenoid saponins that naturally exist in tea seeds. Few articles have focused on the effects and mechanisms of TSS combined with aerobic exercise (AE) in regulating lipid metabolism and improving oxidative damage in vivo. Using an HFD-induced obese mice model to explore the mechanism of TSS + AE in regulating lipid metabolism and its associated oxidative stress damage will help provide reliable data for the application of dietary nutrition combined with AE in anti-obesity.

Keywords: Tea seed saponins; aerobic exercise; high-fat diet; lipid metabolism; obesity; oxidative stress.

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References

REFERENCES

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1. Berge, J., Hjelmesaeth, J., Hertel, J. K., Gjevestad, E., Smastuen, M. C., Johnson, L. K., Martins, C., Andersen, E., Helgerud, J., & Storen, O. (2021). Effect of aerobic exercise intensity on energy expenditure and weight loss in severe obesity-a randomized controlled trial. Obesity, 29, 359-369. https://doi.org/10.1002/oby.23078
1. Brouwers, B., Hesselink, M. K., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2016). Effects of exercise training on intrahepatic lipid content in humans. Diabetologia, 59, 2068-2079. https://doi.org/10.1007/s00125-016-4037-x
1. Capel, F., Rolland-Valognes, G., Dacquet, C., Brun, M., Lonchampt, M., Ktorza, A., Lockhart, B., & Galizzi, J. P. (2013). Analysis of sterol-regulatory element-binding protein 1c target genes in mouse liver during aging and high-fat diet. Journal of Nutrigenet and Nutrigenomics, 6, 107-122. https://doi.org/10.1159/000350751
1. Chen, Y., Li, W., Qiu, S., Vladmir, C., Xu, X., Wang, X., Nian, X., Chen, Q., Wang, Q., Tu, P., Zhang, L., Yan, S., Li, K., Chen, J., Wu, H., Wang, X., Wang, X., Liu, J., Cai, M., … Sun, Z. (2020). Tea consumption and risk of diabetes in the Chinese population: A multi-centre, cross-sectional study. British Journal of Nutrition, 123, 428-436. https://doi.org/10.1017/S000711451900299X

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[1] Arroyave-Ospina, J. C., Wu, Z., Geng, Y., & Moshage, H. (2021). Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy. Antioxidants, 10, 174. https://doi.org/10.3390/antiox10020174

[2] Arroyave-Ospina, J. C., Wu, Z., Geng, Y., & Moshage, H. (2021). Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy. Antioxidants, 10, 174. https://doi.org/10.3390/antiox10020174

[3] Berge, J., Hjelmesaeth, J., Hertel, J. K., Gjevestad, E., Smastuen, M. C., Johnson, L. K., Martins, C., Andersen, E., Helgerud, J., & Storen, O. (2021). Effect of aerobic exercise intensity on energy expenditure and weight loss in severe obesity-a randomized controlled trial. Obesity, 29, 359-369. https://doi.org/10.1002/oby.23078

[4] Berge, J., Hjelmesaeth, J., Hertel, J. K., Gjevestad, E., Smastuen, M. C., Johnson, L. K., Martins, C., Andersen, E., Helgerud, J., & Storen, O. (2021). Effect of aerobic exercise intensity on energy expenditure and weight loss in severe obesity-a randomized controlled trial. Obesity, 29, 359-369. https://doi.org/10.1002/oby.23078

[5] Brouwers, B., Hesselink, M. K., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2016). Effects of exercise training on intrahepatic lipid content in humans. Diabetologia, 59, 2068-2079. https://doi.org/10.1007/s00125-016-4037-x

[6] Brouwers, B., Hesselink, M. K., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2016). Effects of exercise training on intrahepatic lipid content in humans. Diabetologia, 59, 2068-2079. https://doi.org/10.1007/s00125-016-4037-x

[7] Capel, F., Rolland-Valognes, G., Dacquet, C., Brun, M., Lonchampt, M., Ktorza, A., Lockhart, B., & Galizzi, J. P. (2013). Analysis of sterol-regulatory element-binding protein 1c target genes in mouse liver during aging and high-fat diet. Journal of Nutrigenet and Nutrigenomics, 6, 107-122. https://doi.org/10.1159/000350751

[8] Capel, F., Rolland-Valognes, G., Dacquet, C., Brun, M., Lonchampt, M., Ktorza, A., Lockhart, B., & Galizzi, J. P. (2013). Analysis of sterol-regulatory element-binding protein 1c target genes in mouse liver during aging and high-fat diet. Journal of Nutrigenet and Nutrigenomics, 6, 107-122. https://doi.org/10.1159/000350751

[9] Chen, Y., Li, W., Qiu, S., Vladmir, C., Xu, X., Wang, X., Nian, X., Chen, Q., Wang, Q., Tu, P., Zhang, L., Yan, S., Li, K., Chen, J., Wu, H., Wang, X., Wang, X., Liu, J., Cai, M., … Sun, Z. (2020). Tea consumption and risk of diabetes in the Chinese population: A multi-centre, cross-sectional study. British Journal of Nutrition, 123, 428-436. https://doi.org/10.1017/S000711451900299X

[10] Chen, Y., Li, W., Qiu, S., Vladmir, C., Xu, X., Wang, X., Nian, X., Chen, Q., Wang, Q., Tu, P., Zhang, L., Yan, S., Li, K., Chen, J., Wu, H., Wang, X., Wang, X., Liu, J., Cai, M., … Sun, Z. (2020). Tea consumption and risk of diabetes in the Chinese population: A multi-centre, cross-sectional study. British Journal of Nutrition, 123, 428-436. https://doi.org/10.1017/S000711451900299X

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Dietary tea seed saponin combined with aerobic exercise attenuated lipid metabolism and oxidative stress in mice fed a high-fat diet (HFD)

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Dietary tea seed saponin combined with aerobic exercise attenuated lipid metabolism and oxidative stress in mice fed a high-fat diet (HFD)

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