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. 2024 Jan-Feb;38(3):512-522.
doi: 10.1080/14786419.2022.2130915. Epub 2022 Oct 6.

A new cembranoid from the Red Sea soft coral Sarcophyton acutum

Tarik A Mohamed  1 , Seba M Abdelmawgoud  2 , Abdelhamid A Hamdy  2 , Mahmoud A A Ibrahim  3 , Abdelsamed I Elshamy  4 , Mohamed A M Atia  5 , Hanaa A Kassem  6 , Mohamed-Elamir F Hegazy  1 , Nabil M Selim  6
Affiliations

A new cembranoid from the Red Sea soft coral Sarcophyton acutum

Tarik A Mohamed et al. Nat Prod Res. 2024 Jan-Feb.

Abstract

The Red Sea soft coral Sarcophyton acutum ethyl acetate extract has afforded one new cembranoid; sarcacutumolid A (1), along with six known metabolites have been isolated from S. acutum for the first time (2-7). Chemical structures were elucidated by employing several spectroscopic analyses. The cytotoxic potential of the isolated compounds was assessed against four human cancer cell lines; hepatocellular (HepG2), cervical (HeLa), breast (MCF-7) and colorectal cancer (Colo-205). Sarcacutumolid A (1) and gorgosterol (7) inhibited colorectal cancer cell proliferation in a concentration-dependent manner with IC50 values of 35.5 and 44.0 μM, respectively.

Keywords: Sarcophyton acutum; Soft coral; cembranoids; cytotoxic activity; diterpenenoid.

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