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Comment
. 2022 Oct 7;378(6615):28-29.
doi: 10.1126/science.ade4210. Epub 2022 Oct 6.

A perturbed network in neurodegeneration

Jean-Marc Gallo  1 , Dieter Edbauer  2   3   4
Affiliations
Comment

A perturbed network in neurodegeneration

Jean-Marc Gallo et al. Science. .

Abstract

Three proteins act in concert to cause neuronal pathology.

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  • Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration.
    Shao W, Todd TW, Wu Y, Jones CY, Tong J, Jansen-West K, Daughrity LM, Park J, Koike Y, Kurti A, Yue M, Castanedes-Casey M, Del Rosso G, Dunmore JA, Zanetti Alepuz D, Oskarsson B, Dickson DW, Cook CN, Prudencio M, Gendron TF, Fryer JD, Zhang YJ, Petrucelli L. Shao W, et al. Science. 2022 Oct 7;378(6615):94-99. doi: 10.1126/science.abq7860. Epub 2022 Oct 6. Science. 2022. PMID: 36201573 Free PMC article.

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