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Editorial
. 2023 Feb 1;207(3):240-242.
doi: 10.1164/rccm.202209-1709ED.

miR-roring Changes in Blood: miR-210 Reflects Hypoxic Disease Dynamics in Obstructive Sleep Apnea

Anna Kirillova  1   2 , Stephen Y Chan  1
Affiliations
Editorial

miR-roring Changes in Blood: miR-210 Reflects Hypoxic Disease Dynamics in Obstructive Sleep Apnea

Anna Kirillova et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Obstructive sleep apnea (OSA) and intermittent hypoxia induce elevated concentrations of endothelial and circulating microRNA-210 (miR-210). SREBP2 (sterol regulatory element-binding protein 2) directly binds to the promoter of miR-210, leading to suppression of ISCUs (iron-sulfur assembly enzyme) in the mitochondria of the vascular endothelium. Hypoxic stressors in addition to further input from the proposed axis drive compromised mitochondrial respiration and function. These findings may have broad relevance to numerous human pathological states affected by intermittent hypoxia, as seen in OSA, and pave the way for future research into the utility of miR-210 as a therapeutic and prognostic marker. Images created with BioRender.
See this image and copyright information in PMC

Comment on

  • Obstructive Sleep Apnea-induced Endothelial Dysfunction Is Mediated by miR-210.
    Shang F, Wang SC, Gongol B, Han SY, Cho Y, Schiavon CR, Chen L, Xing Y, Zhao Y, Ning M, Guo X, He F, Lei Y, Wang L, Manor U, Marin T, Chou KT, He M, Huang PH, Shyy JY, Malhotra A. Shang F, et al. Am J Respir Crit Care Med. 2023 Feb 1;207(3):323-335. doi: 10.1164/rccm.202202-0394OC. Am J Respir Crit Care Med. 2023. PMID: 36191258 Free PMC article.

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