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Comment
. 2022 Dec 1;60(6):2201795.
doi: 10.1183/13993003.01795-2022. Print 2022 Dec.

Reply: U-BIOPRED/BIOAIR proteins: inflammation or infection?

Maria Sparreman Mikus  1   2   3 , Johan Kolmert  3   4 , Lars I Andersson  5   2   3 , Sven-Erik Dahlén  5   2   3   4 , Anna James  3   4
Affiliations
Comment

Reply: U-BIOPRED/BIOAIR proteins: inflammation or infection?

Maria Sparreman Mikus et al. Eur Respir J. .

Abstract

Protein profiles in plasma remained associated with asthma severity in the European asthma cohort U-BIOPRED when controlling for previous history of respiratory infections https://bit.ly/3rdEL0O

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Conflict of interest statement

Conflict of interest: S-E. Dahlén reports personal fees for consultancy from AZ, Cayman Chemical, GSK, Novartis, Regeneron, Sanofi and Teva, outside the submitted work. The remaining authors disclose no potential conflicts of interest.

Figures

FIGURE 1
FIGURE 1
a) Previous history of respiratory infections among asthmatics in the U-BIOPRED cohort. Respiratory infections were defined as at least one of bronchitis, chronic bronchitis or pneumonia. b) Association with respiratory infections per asthma group and with asthma severity given no history or previous history of respiratory infections (bronchitis, chronic bronchitis and/or pneumonia). Relative signal intensity depicted on y-axis. *: p<0.05, **: p<0.01, ***: p<0.001, and ****: p<0.0001 from Wilcoxon rank-sum tests. MMA: non-smokers with mild-to-moderate asthma; SAn: non-smokers with severe asthma; SAs/ex: smokers or ex-smokers with severe asthma; APOE: apolipoprotein E; C9: complement component 9; CCL23: macrophage inflammatory protein-3; CFI: complement factor I; GSTP1: glutathione S-transferase P; IL-6: interleukin-6; SERPINA3: alpha-1-antichymotrypsin; SMPD3: sphingomyelin phosphodiesterase 3; TGF-β1: transforming growth factor β1; TNFRSF11A: tumour necrosis factor receptor superfamily member 11a.
See this image and copyright information in PMC

Comment on

  • Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.
    Sparreman Mikus M, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Emami Khoonsari P, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Niżankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlén M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A; U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group and the BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium. Sparreman Mikus M, et al. Eur Respir J. 2022 Feb 17;59(2):2100142. doi: 10.1183/13993003.00142-2021. Print 2022 Feb. Eur Respir J. 2022. PMID: 34737220 Free PMC article. Clinical Trial.
  • U-BIOPRED/BIOAIR proteins: inflammation or infection?
    Hahn DL, Webley W. Hahn DL, et al. Eur Respir J. 2022 Dec 1;60(6):2200571. doi: 10.1183/13993003.00571-2022. Print 2022 Dec. Eur Respir J. 2022. PMID: 36202417 No abstract available.

References

    1. Sparreman Mikus M, Kolmert J, Andersson LI, et al. . Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation. Eur Respir J 2022; 59: 2100142. doi:10.1183/13993003.00142-2021 - DOI - PMC - PubMed
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