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. 2022 Oct;15(10):1821-1824.
doi: 10.1016/j.jcmg.2022.01.008. Epub 2022 Mar 16.

Cardiac Magnetic Resonance Imaging Midterm Follow Up of COVID-19 Vaccine-Associated Myocarditis

João L Cavalcante  1 , Kirsten E Shaw  2 , Mario Gössl  3
Affiliations

Cardiac Magnetic Resonance Imaging Midterm Follow Up of COVID-19 Vaccine-Associated Myocarditis

João L Cavalcante et al. JACC Cardiovasc Imaging. 2022 Oct.
No abstract available

Keywords: CMR; COVID-19; myocarditis; vaccination.

PubMed Disclaimer

Conflict of interest statement

Funding Support and Author Disclosures Dr Cavalcante has reported research support from Circle Cardiovascular Imaging and Siemens Healthineers. Dr Gössl has reported consulting for Abbott Vascular. Dr Shaw has reported that she has no relationships relevant to the contents of this paper to disclose.

Figures

Figure 1
Figure 1
Initial and Follow-Up CMR of Patient 1 (A to D) Initial cardiac magnetic resonance (CMR) of patient 1 that demonstrates (A and C) inferior and inferolateral epicardial edema on T2 mapping (region of interest #1 >55 ms, which is supportive of regional edema) and (B and D) corresponding nonischemic myocardial injury on imaging with late gadolinium enhancement (LGE) in a skip pattern, consistent with acute myocarditis according to the 2018 updated Lake Louise criteria. (E to H) Follow-up CMR demonstrating resolution of myocarditis without myocardial edema, scarring, or fibrosis.
Figure 2
Figure 2
Initial and Follow-Up CMR of Patient 2 (A to D) Initial CMR of patient 2 demonstrating (A and C) myocardial edema and (B and D) epicardial to midmyocardial gadolinium uptake in a skip pattern consistent with acute myocarditis. (E to H) Follow-up CMR demonstrating (E and G) complete resolution of myocardial edema, with (F and H) discrete epicardial nonischemic fibrosis in the basilar inferior and inferolateral wall. 1 and 2 = regions of interest. Abbreviation as in Figure 1.
Figure 3
Figure 3
Initial and Follow-Up CMR of Patient 3 (A to D) Initial CMR of patient 3 demonstrating (A and C) prominent myocardial edema and (B and D) LGE of the basal inferior and inferolateral walls consistent with acute myocarditis. (E to H) Follow-up CMR demonstrating (E and G) resolution of myocardial edema and (F and H) decrease in nonischemic LGE, consistent with the transition from injury or inflammation to replacement fibrosis. 1 and 2 = regions of interest. Abbreviations as in Figure 1.
Figure 4
Figure 4
Initial and Follow-Up CMR of Patient 4 (A to D) Initial CMR of patient 4 demonstrating (A and C) epicardial edema on basal inferior, lateral, and middle anterolateral segments and (B and D) nonischemic myocardial injury involving the basal lateral and middle anterolateral segments in skip lesions on LGE imaging consistent with acute myocarditis. (E to H) Follow-up CMR demonstrating (E and G) resolution in myocardial edema and (F and H) improvement of nonischemic fibrosis along the basal lateral wall. 1 and 2 = regions of interest. Abbreviations as in Figure 1.
Figure 5
Figure 5
Initial and Follow-Up CMR of Patient 5 (A to D) Initial CMR of patient 5 demonstrating (A and C) discrete myocardial edema in the mid anterolateral and (B and D) the corresponding nonischemic myocardial injury consistent with acute myocarditis. (E to H) Follow-up CMR demonstrating (E and G) resolved myocardial edema and (F) nearly resolved areas of gadolinium uptake but (H) still present in the epicardium of the midlateral to apical lateral wall. 1 and 2 = regions of interest. Abbreviation as in Figure 1.
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