MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We?

Abstract

Patients with diffuse lung diseases require thorough medical and social history and physical examinations, coupled with a multitude of laboratory tests, pulmonary function tests, and radiologic imaging to discern and manage the specific disease. This review summarizes the current state of imaging of various diffuse lung diseases by hyperpolarized MR imaging. The potential of hyperpolarized MR imaging as a clinical tool is outlined as a novel imaging approach that enables further understanding of the cause of diffuse lung diseases, permits earlier detection of disease progression before that found with pulmonary function tests, and can delineate physiologic response to lung therapies.

Keywords: COPD; Cystic fibrosis; Diffuse lung disease; Hyperpolarized (129)Xenon MR imaging; ILD; Long-COVID; MR imaging; Pulmonary imaging.