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Comment
. 2022 Dec;18(12):681-682.
doi: 10.1038/s41584-022-00859-4.

Keeping immunostimulatory self-RNA under the rADAR

Christine Wolf  1 , Min Ae Lee-Kirsch  2
Affiliations
Comment

Keeping immunostimulatory self-RNA under the rADAR

Christine Wolf et al. Nat Rev Rheumatol. 2022 Dec.
No abstract available

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Comment on

  • ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
    de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J. de Reuver R, et al. Nature. 2022 Jul;607(7920):784-789. doi: 10.1038/s41586-022-04974-w. Epub 2022 Jul 20. Nature. 2022. PMID: 35859175
  • ADAR1 averts fatal type I interferon induction by ZBP1.
    Jiao H, Wachsmuth L, Wolf S, Lohmann J, Nagata M, Kaya GG, Oikonomou N, Kondylis V, Rogg M, Diebold M, Tröder SE, Zevnik B, Prinz M, Schell C, Young GR, Kassiotis G, Pasparakis M. Jiao H, et al. Nature. 2022 Jul;607(7920):776-783. doi: 10.1038/s41586-022-04878-9. Epub 2022 Jul 20. Nature. 2022. PMID: 35859176 Free PMC article.
  • ADAR1 mutation causes ZBP1-dependent immunopathology.
    Hubbard NW, Ames JM, Maurano M, Chu LH, Somfleth KY, Gokhale NS, Werner M, Snyder JM, Lichauco K, Savan R, Stetson DB, Oberst A. Hubbard NW, et al. Nature. 2022 Jul;607(7920):769-775. doi: 10.1038/s41586-022-04896-7. Epub 2022 Jul 20. Nature. 2022. PMID: 35859177 Free PMC article.

References

    1. Rice, G. I. et al. Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature. Nat. Genet. 44, 1243–1248 (2012). - DOI - PubMed - PMC
    1. Liddicoat, B. J. et al. RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science 349, 1115–1120 (2015). - DOI - PubMed - PMC
    1. Pestal, K. et al. Isoforms of RNA-editing enzyme ADAR1 independently control nucleic acid sensor MDA5-driven autoimmunity and multi-organ development. Immunity 43, 933–944 (2015). - DOI - PubMed - PMC
    1. Bajad, P. et al. An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype. Nucleic Acids Res 48, 3286–3303 (2020). - DOI - PubMed - PMC
    1. Hubbard, N. W. et al. ADAR1 mutation causes ZBP1-dependent immunopathology. Nature 607, 769–775 (2022). - DOI - PubMed

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