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. 2023 Jan;27(1):12-20.
doi: 10.1111/hdi.13047. Epub 2022 Oct 6.

Systematic review of locking solutions for non-tunneled hemodialysis catheters

Isabelle Boucley  1 , Auguste Dargent  2 , Pascal Andreu  1 , Jean-Baptiste Roudaut  1 , François Aptel  1 , Marie Labruyère  1 , Marine Jacquier  1 , Amélie Cransac  3   4 , Jean-Pierre Quenot  1   5   6
Affiliations

Systematic review of locking solutions for non-tunneled hemodialysis catheters

Isabelle Boucley et al. Hemodial Int. 2023 Jan.

Abstract

Background: We conducted a systematic review of studies investigating lock solutions for use in non-tunneled hemodialysis catheters.

Methods: We searched PubMed and Cochrane databases from inception to June 11, 2021. Study inclusion criteria were: randomized trial or observational study, adults (>18 years), with acute kidney injury (AKI); and temporary non-tunneled catheters. We recorded bleeding events, catheter dysfunction and complications.

Results: Of 649 studies identified, 6 were included (4 randomized, 1 non-randomized trial, 1 retrospective cohort study; sample sizes 78-1496 patients). Citrate was compared to heparin in 4 studies, to saline in 1, and ethanol versus saline in 1. Event-free survival of non-tunneled catheters did not differ between groups. Catheter-related infections and adverse events were less frequent with citrate locks, but reached statistical significance in only two studies.

Conclusion: Existing data are too heterogeneous to enable recommending one type of catheter lock over any other for non-tunneled hemodialysis catheters.

Keywords: intensive care unit; locking solutions; non-tunneled hemodialysis catheters.

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Conflict of interest statement

No author has any conflict of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Flow chart of the selection of studies for inclusion in the review [Color figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

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