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Review
. 2022 Sep 20:12:1006114.
doi: 10.3389/fonc.2022.1006114. eCollection 2022.

Natural products exert anti-tumor effects by regulating exosomal ncRNA

Shuang Hu  1 , Yi Liu  1 , Shuguang Guan  1 , Zhidong Qiu  1 , Da Liu  1
Affiliations
Review

Natural products exert anti-tumor effects by regulating exosomal ncRNA

Shuang Hu et al. Front Oncol. .

Abstract

Currently, more than 60% of the approved anti-cancer drugs come from or are related to natural products. Natural products and exosomal non-coding RNAs (ncRNAs) exert anti-cancer effects through various regulatory mechanisms, which are of great research significance. Exosomes are a form of intercellular communication and contain ncRNAs that can act as intercellular signaling molecules involved in the metabolism of tumor cells. This review exemplifies some examples of natural products whose active ingredients can play a role in cancer prevention and treatment by regulating exosomal ncRNAs, with the aim of illustrating the mechanism of action of exosomal ncRNAs in cancer prevention and treatment. Meanwhile, the application of exosomes as natural drug delivery systems and predictive disease biomarkers in cancer prevention and treatment is introduced, providing research ideas for the development of novel anti-tumor drugs.

Keywords: biomarkers; cancer treatment; exosomes ncRNAs; exosomes vector; natural products.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The structure and secretion mode of exosomes.
Figure 2
Figure 2
Number of articles related to ncRNAs.
Figure 3
Figure 3
Natural drugs improve the TME by regulating exosomal ncRNAs.
Figure 4
Figure 4
Natural drugs regulate exosomal ncRNAs to promote tumor cell apoptosis or inhibit.
See this image and copyright information in PMC

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