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Case Reports
. 2022 Sep 20:12:945689.
doi: 10.3389/fonc.2022.945689. eCollection 2022.

Case report: A rare occurrence of triple malignancy of the stomach, rectum and liver in a single patient

Cancan Jin  1 , Jiangnan Hu  2 , Kirthikaa Balapattabi  3 , Brian Wang  4 , Sizhe Hu  1 , Kangyi Wang  1 , Liangbin Fu  1 , Xiaokang Zhao  1 , Feng Qian  1 , Zhen Wang  5
Affiliations
Case Reports

Case report: A rare occurrence of triple malignancy of the stomach, rectum and liver in a single patient

Cancan Jin et al. Front Oncol. .

Abstract

Malignant tumors of the digestive system are common worldwide; however, it is extremely rare for more than two malignancies to occur simultaneously. Here, we report a case with a triple malignancy of the digestive system, including gastric, rectal, and hepatic tumors. The patient underwent surgical resection of three tumors followed by chemotherapy. Negative image-based screenings and the absence of serum tumor biomarkers elevation were found at 2.5 years after the surgery, indicating the absence of recurrence and metastasis of cancers.

Keywords: gastric carcinoma; hepatocellular carcinoma; immune checkpoint inhibitors; rectal carcinoma; surgery.

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Conflict of interest statement

Author BW was employed by Pathnova Laboratories Pte. Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Timeline outlining clinical events.
Figure 2
Figure 2
Diagnosis of gastric carcinoma. (A) Endoscopic images showing gastric cancer. (B) Gastric cancer (indicated by yellow arrow), specific enhancement pattern on multiphasic contrast-enhanced computed tomography (CT). (C) Representative histopathological image of gastric cancer.
Figure 3
Figure 3
Diagnosis of primary liver cancer. (A) Liver cancer seen on contrast-enhanced CT (arterial phase), indicated by yellow arrow. (B) Liver cancer seen on contrast-enhanced CT (venous phase), indicated by arrow. (C) Representative histopathological image of liver cancer.
Figure 4
Figure 4
Diagnosis of rectal carcinoma. (A) Endoscopic images indicating rectal carcinoma (yellow arrow). (B) Contrast-enhanced CT showing rectal cancer. (C) Representative histopathological image of rectal carcinoma.
See this image and copyright information in PMC

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