Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep;5(3):239-248.
doi: 10.1055/s-0041-1729945.

Precision Medicine for Obesity

Lizeth Cifuentes  1 , Maria Daniela Hurtado A  1   2 , Jeanette Eckel-Passow  3 , Andres Acosta  1
Affiliations

Precision Medicine for Obesity

Lizeth Cifuentes et al. Dig Dis Interv. 2021 Sep.

Abstract

Obesity is a multifactorial disease with a variable and underwhelming weight loss response to current treatment approaches. Precision medicine proposes a new paradigm to improve disease classification based on the premise of human heterogeneity, with the ultimate goal of maximizing treatment effectiveness, tolerability, and safety. Recent advances in high-throughput biochemical assays have contributed to the partial characterization of obesity's pathophysiology, as well as to the understanding of the role that intrinsic and environmental factors, and their interaction, play in its development and progression. These data have led to the development of biological markers that either are being or will be incorporated into strategies to develop personalized lines of treatment for obesity. There are currently many ongoing initiatives aimed at this; however, much needs to be resolved before precision obesity medicine becomes common practice. This review aims to provide a perspective on the currently available data of high-throughput technologies to treat obesity.

Keywords: ADOPT; genetics; microbiome; phenotypes.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Precision medicine integrates the biomarker data from -omics, lifestyle, psychosocial, and environmental factors.
Fig. 2
Fig. 2
Multi-omics.
See this image and copyright information in PMC

References

    1. Afshin A, Forouzanfar MH, Reitsma MB, et al.; GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 2017;377(01):13–27 - PMC - PubMed
    1. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009;9:88. - PMC - PubMed
    1. Nyberg ST, Batty GD, Pentti J, et al. Obesity and loss of disease-free years owing to major non-communicable diseases: a multi-cohort study. Lancet Public Health 2018;3(10):e490–e497 - PMC - PubMed
    1. Waters H, Graf M. America’s Obesity Crisis:The Health and Economic Costs of Excess Weight. The Milken Institute; October 26, 2018
    1. Ward ZJ, Bleich SN, Cradock AL, et al. Projected U.S. state-level prevalence of adult obesity and severe obesity. N Engl J Med 2019;381(25):2440–2450 - PubMed

LinkOut - more resources