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Case Reports
. 2022 Jan-Mar;12(1):91-94.
doi: 10.4103/jwas.jwas_74_22. Epub 2022 Aug 23.

Osteosarcoma Arising From a Cervical Teratoma in a 4-year Old Child: A Report of a Rare Case and Literature Review

Kenneth Ezenwa Amaefule  1 , Friday Samuel Ejagwulu  1 , Talib Talib Sholadoye  2 , Waziri Garba Dahiru  3
Affiliations
Case Reports

Osteosarcoma Arising From a Cervical Teratoma in a 4-year Old Child: A Report of a Rare Case and Literature Review

Kenneth Ezenwa Amaefule et al. J West Afr Coll Surg. 2022 Jan-Mar.

Abstract

Cervical teratomas consist of about 3% of all teratomas, and commonly present in childhood. They are often benign and very rarely turn malignant. Malignant transformation of teratomas occurs in about 3% - 6% of such tumours, and often results in carcinomas, and infrequently, sarcomas and yolk sac tumours. Squamous cell carcinoma accounts for about 80% - 90% of such malignant transformation. Osteosarcoma arising from a teratoma is a rare occurrence with the very few reported cases occurring in the ovaries, and no such transformation has been reported in a cervical teratoma. We present our experience with a child with osteosarcoma in a cervical teratoma.

Keywords: Cervical teratoma; malignant transformation; osteosarcoma.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Clinical photograph
Figure 2
Figure 2
Clinical photograph
Figure 3
Figure 3
Ultrasonographic image
Figure 4
Figure 4
FNAB report
Figure 5
Figure 5
Histopathological sections and report. Section from A (x400) shows malignant spindle cells forming osteoid shows. Section from B (x10,000) shows higher magnification of the malignant spindle cells with osteoid formation. Section from C shows show numerous vascular channels admixed malignant cells. Section from D shows primitive neural cells.
Figure 6
Figure 6
Radiograph
See this image and copyright information in PMC

References

    1. Rothschild MA, Catalano P, Urken M, Brandwein M, Som P, Norton K, et al. Evaluation and management of congenital cervical teratoma. Case report and review. Arch Otolaryngol Head Neck Surg. 1994;120:444–8. - PubMed
    1. Comiter CV, Kibel AS, Richie JP, Nucci MR, Renshaw AA. Prognostic features of teratomas with malignant transformation: A clinicopathological study of 21 cases. J Urol. 1998;159:859–63. - PubMed
    1. Aygun B, Kimpo M, Lee T, Valderrama E, Leonidas J, Karayalcin G. An adolescent with ovarian osteosarcoma arising in a cystic teratoma. J Pediatr Hematol Oncol. 2003;25:410–3. - PubMed
    1. Ajithkumar TV, Abraham EK, Nair MK. Osteosarcoma arising in a mature cystic teratoma of the ovary. J Exp Clin Cancer Res. 1999;18:89–91. - PubMed
    1. Kumar V, Abbas AK, Aster JC. Neoplasia. In: Kumar V, Abbas AK, Aster JC, editors. Robbins and Cotran Pathologic Basis of Diseases. 9th ed. Philadelphia: Elsevier; 2015. pp. 265–340.

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