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. 2022 Sep 20:13:987618.
doi: 10.3389/fneur.2022.987618. eCollection 2022.

Time trends in the incidence of essential tremor: Evidences from UK and France primary care data

Ippazio Cosimo Antonazzo  1 , Sara Conti  1 , Davide Rozza  1 , Carla Fornari  1 , Caroline Eteve-Pitsaer  2 , Claire Paris  2 , Laurène Gantzer  2 , Dennis Valentine  3 , Lorenzo Giovanni Mantovani  1 , Giampiero Mazzaglia  1
Affiliations

Time trends in the incidence of essential tremor: Evidences from UK and France primary care data

Ippazio Cosimo Antonazzo et al. Front Neurol. .

Abstract

Introduction: Although essential tremor (ET) is considered a common adult movement disorder, evidence on its incidence is still scant. This study aims at estimating ET incidence in two European countries, namely, the UK and France.

Methods: Incident cases of ET were identified within the Health Improvement Network (THIN®) database between 1st January 2014 and 31 December 2019. Yearly crude and standardized incidence rates (IR) were estimated across the study period for both countries. Poisson regression models were built to assess temporal trends in IRs and differences between sexes and age classes.

Results: In total, 4,970 and 4,905 incident cases of ET were identified in the UK and France, respectively. The yearly average crude IR (per 100,000 person-years) was 18.20 (95%CI: 15.09-21.32) in UK and 21.42 (17.83-25.00) in France, whereas standardized ones were 19.51 (18.97-20.01) and 19.50 (18.97-20.05). Regression analyses showed slightly increasing trends in both countries, higher incidence among males, and a significant increase with age. Yearly average IR increased from 3.96 (0.95-6.97) and 5.28 (1.12-9.44) in subjects aged <20 years to 49.27 (26.29-72.24) and 51.52 (30.19-72.86) in those aged >80 year in UK and France.

Conclusions: Standardized ET incidence was comparable in the UK and France, showing a slight increase in both countries, reporting a higher value among people aged 60 years and older. This study outlines the need to conduct future studies to estimate the burden of ET in terms of disease control and healthcare resource utilization.

Keywords: France; THIN® database; United Kingdom; epidemiology; essential tremor.

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Conflict of interest statement

Author LM has received grants and personal fees from Bayer AG, Boehringer Ingelheim, Pfizer and Daiichi-Sankyo. Authors CE-P, CP, LG, and DV are employed by Cegedim. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Incidence of essential tremor (ET) incidence in the United Kingdom and France between 2014 and 2019. (A) Standardized yearly incidence rates for UK; (B) Standardized yearly incidence rates for France; (C) Standardized incidence rate for UK, stratified by sex; (D) Standardized incidence rates for France, stratified by sex; (E) Age-specific rates for UK; (F) Age-specific rates for France.
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