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. 2022 Sep 20:13:1006870.
doi: 10.3389/fgene.2022.1006870. eCollection 2022.

Correlation of the position and status of the polar body from the fertilized oocyte to the euploid status of blastocysts

Yongle Yang  1 , Wei Tan  2 , Changsheng Chen  2 , Lei Jin  1 , Bo Huang  1
Affiliations

Correlation of the position and status of the polar body from the fertilized oocyte to the euploid status of blastocysts

Yongle Yang et al. Front Genet. .

Abstract

Polar bodies are tiny cells that are extruded during oocyte meiosis and are generally considered not essential for embryonic development. Therefore, polar bodies have been widely used as important materials for the preimplantation genetic diagnosis of human embryos. Recent studies have shown that polar bodies mediate embryonic development and that their morphology is related to embryo quality and developmental potential. However, the relationship between the emission of the polar body and embryonic euploidy remains unclear. In this study, a total of 1,360 blastocyst trophectoderm (TE) biopsies were performed, and blastocyst ploidy results were correlated with the state of polar bodies. The results showed that polar body angle size and polar body status are not directly related to whether the blastocysts are euploid, aneuploid, or mosaic (p > 0.05). Therefore, in the process of clinical embryo selection, embryologists should not predict the euploidy of blastocysts based on the state of polar bodies, thus affecting embryo selection.

Keywords: aneuploidy; blastocyst; euploidy; mosaicism; polar body.

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Conflict of interest statement

Author WT and CC was employed by the Wuhan Huchuang Union Technology Co.,Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Group by polar body position. GroupⅠ: pole body angle≤30°; GroupⅡ: polar body angle between 30° and 90°; GroupⅢ pole body angle ≥90°.
FIGURE 2
FIGURE 2
Polar body angle and embryo euploidy.
FIGURE 3
FIGURE 3
Polar body morphology and embryo euploidy.
FIGURE 4
FIGURE 4
Time of the second polar body emission.
See this image and copyright information in PMC

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