Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Sep 20:13:930495.
doi: 10.3389/fmicb.2022.930495. eCollection 2022.

Interactions between Candida albicans and the resident microbiota

Hao Li  1   2 , Ming-Xing Miao  2 , Cheng-Lin Jia  3 , Yong-Bing Cao  3 , Tian-Hua Yan  2 , Yuan-Ying Jiang  1 , Feng Yang  1
Affiliations
Review

Interactions between Candida albicans and the resident microbiota

Hao Li et al. Front Microbiol. .

Abstract

Candida albicans is a prevalent, opportunistic human fungal pathogen. It usually dwells in the human body as a commensal, however, once in its pathogenic state, it causes diseases ranging from debilitating superficial to life-threatening systemic infections. The switch from harmless colonizer to virulent pathogen is, in most cases, due to perturbation of the fungus-host-microbiota interplay. In this review, we focused on the interactions between C. albicans and the host microbiota in the mouth, gut, blood, and vagina. We also highlighted important future research directions. We expect that the evaluation of these interplays will help better our understanding of the etiology of fungal infections and shed new light on the therapeutic approaches.

Keywords: Candida albicans; biofilm; candidiasis; microbiota; polymicrobial disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abu-Elteen K. H., Abu-Alteen R. M. (1998). The prevalence of Candida albicans populations in the mouths of complete denture wearers. New Microbiol. 21 41–48. - PubMed
    1. Aguiar Cordeiro R., de Jesus Evangelista A. J., Serpa R., Colares, de Andrade A. R., Leite Mendes P. B., et al. (2018). beta-lactam antibiotics & vancomycin increase the growth & virulence of Candida spp. Future Microbiol. 13 869–875. 10.2217/fmb-2018-2019 - DOI - PubMed
    1. Allison D. L., Scheres N., Willems H. M. E., Bode C. S., Krom B. P., Shirtliff M. E. (2019). The host immune system facilitates disseminated Staphylococcus aureus disease due to phagocytic attraction to Candida albicans during coinfection: a case of bait and switch. Infect. Immun. 87:e00137-19. 10.1128/iai.00137-119 - DOI - PMC - PubMed
    1. Allonsius C. N., van den Broek M. F. L., De Boeck I., Kiekens S., Oerlemans E. F. M., Kiekens F., et al. (2017). Interplay between Lactobacillus rhamnosus GG and Candida and the involvement of exopolysaccharides. Microb Biotechnol. 10 1753–1763. 10.1111/1751-7915.12799 - DOI - PMC - PubMed
    1. Allonsius C. N., Vandenheuvel D., Oerlemans E. F. M., Petrova M. I., Donders G. G. G., Cos P., et al. (2019). Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG. Sci. Rep. 9:2900. 10.1038/s41598-019-39625-39620 - DOI - PMC - PubMed

LinkOut - more resources