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. 2023 Dec;34(1):2131703.
doi: 10.1080/09546634.2022.2131703. Epub 2022 Oct 17.

Topical prebiotics/postbiotics and PRURISCORE validation in atopic dermatitis. International study of 396 patients

Carlo Gelmetti  1 , Corinna Rigoni  2 , Alessandra Maria Cantù  2 ; members of the Italian Groupb (in alphabetical order):; Antonina Agolzer, Alice Agrusa, Michela Brena, Federica Dall'Oglio, Patrizia Demichelis, Sandra Farina, Lucretia Adina Frasin, Sandra Lorenzi, Giuseppina Mazzola, Marisa Praticò, Stefania Robotti, Aurora Tedeschi, Lucia Villa; members of the international “ad hoc” Group  2 ; (in alphabetical order):; Prodromos Ananiadis, Eirini Arkoumani, Iulia Astashonok, Eulalia Baselga Torres, Sidita Borici, Elna Cano, Rozana Cela, Amarda Cengo, Francisca Corella, Xavier Cubiro Raventos, Miriam America De Jesus Silva, Ermira Demiraj, Entela Dhima, Xhiljola Doci, Anna Domarad, Marina Didyk, Albana Dyli, Ourania Efthimiou, Georgia Filippi, Víctor-Adrian Flores Climente, Maria Pilar Garcia Muret, Javier Garcia Navarro, Migena Gega, Aristea Noura Giakoub, Vasileios Giakoubis, Amarda Gica, Marjeta Gjomema, Blerina Guri, Elmijola Janushaj, Antonios Kanelleas, Georgia Kanelopoulou, Entela Kapaj, Dorothea Kapoukranidou, Konstantina Karadima, Athina Katsavou, Lena Kotrulja, Aikaterini Kyriakou, Georgios Larios, Anna Lopez, Cristina Lopez, Sofia Magdalini Manoli, Tatiana Matvienko, Liljana Mervic, Konstantinos Mileounis, Diana Muja, Milkota Nadezhda, Despoina Panagioti, Markos Papakonstantis, Maria Papanikou, Despoina Papathemeli, Kyriaki Papigkioti, Violetta Pivak, Driada Preza, Esther Roé, Mirjam Rogl Butina, Esther Serra Baldrich, Dimitrios Sgouros, Aleksandra Shilova, Eljona Shllaku, Nikolaos Sideris, Ermal Sina, Ardiana Sinani, Fani Sourli-Chasioti, Mirsa Stankaj, Dimitra Tasioula, Athanasios Tsalmadoupis, Fragkiski Tsatsou, Eftichia Tsenebi, Anastasia Tsitlakidou, Politimos Vassis, Eva Vilarrassa, Olga Vorobey, Nikolaos Voutsakis, Svetlana Yakovleva, Svetlana Yakubovskaya, Ekaterina Yerygina, Alexios Zarras, Valbona Zenelaj, Olga Zenko
Affiliations
Free article

Topical prebiotics/postbiotics and PRURISCORE validation in atopic dermatitis. International study of 396 patients

Carlo Gelmetti et al. J Dermatolog Treat. 2023 Dec.
Free article

Abstract

Aim: To investigate the efficacy and tolerability of a cream (Rilastil Xerolact PB) containing a mixture of prebiotics and postbiotics, and to validate the PRURISCORE itch scale in the management of atopic dermatitis.Methods: The study is based on 396 subjects of both sexes in three age groups (i.e., infants, children, adults) suffering from mild/moderate Atopic Dermatitis, recruited from 8 European countries and followed for 3 months.Results: The product demonstrated good efficacy combined with good/very good tolerability in all age groups. In particular, SCORAD, PRURISCORE and IGA scores decreased significantly over the course of the study. The PRURISCORE was preferred to VAS by the vast majority of patients.Conclusion: Even though the role of prebiotics and postbiotics was not formally demonstrated since these substances were part of a complex formulation, it can be reasonably stated that prebiotics and postbiotics have safety and standardization features that probiotics do not have. In addition they are authorized by regulatory authorities, whereas topical probiotics are not.

Keywords: Atopic dermatitis; PRURISCORE; Quality of Life; postbiotics; prebiotics.

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