A new tolerogenic cell RORs onto the scene

Sam J Olyha¹, Stephanie C Eisenbarth^{1

2}

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
² Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Comment

Sam J Olyha et al. Sci Immunol. 2022.

. 2022 Oct 14;7(76):eadf0767.

doi: 10.1126/sciimmunol.adf0767. Epub 2022 Oct 7.

Sam J Olyha¹, Stephanie C Eisenbarth^{1

2}

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
² Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

Differentiation of microbe-specific T_regs in the gut is directed by RORγt⁺ antigen-presenting cells.

A RORγt⁺ cell instructs gut microbiota-specific T_reg cell differentiation.
Kedmi R, Najar TA, Mesa KR, Grayson A, Kroehling L, Hao Y, Hao S, Pokrovskii M, Xu M, Talbot J, Wang J, Germino J, Lareau CA, Satpathy AT, Anderson MS, Laufer TM, Aifantis I, Bartleson JM, Allen PM, Paidassi H, Gardner JM, Stoeckius M, Littman DR. Kedmi R, et al. Nature. 2022 Oct;610(7933):737-743. doi: 10.1038/s41586-022-05089-y. Epub 2022 Sep 7. Nature. 2022. PMID: 36071167 Free PMC article.