Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Jul 1;51(6):563-567.
doi: 10.1097/MPA.0000000000002073.

Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality

Jose Serrano  1 , Maren R Laughlin  2 , Melena D Bellin  3 , Dhiraj Yadav  4 , Vernon M Chinchilli  5 , Dana K Andersen  1 ; Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)
Collaborators, Affiliations
Meta-Analysis

Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality

Jose Serrano et al. Pancreas. .

Abstract

Acute pancreatitis (AP), resulting from inflammation of the pancreas, accounts for more than 300,000 US hospital discharges per year. Although glucose intolerance has been known as a complication of severe AP, this effect was thought to be transient. Recently, cohort studies and meta-analysis of 24 published studies of 1100 patients who survived one or more episodes of AP revealed that 30% to 40% of patients developed diabetes or impaired glucose tolerance within 3 to 4 years of even a single episode of AP. The National Institute of Diabetes and Digestive and Kidney Diseases funded the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) to undertake a prospective observational study of the occurrence of diabetes during an AP episode or subsequently, with emphasis on type 1 diabetes. Key factors for funding T1DAPC are the increasing incidence and prevalence of AP, its association with the development of type 1 diabetes and other forms of diabetes after AP, its complications, and associated health care cost. The T1DAPC structure, governance, and research objectives are described in this article. The DREAM (Diabetes RElated to Acute pancreatitis and its Mechanisms) studies to be undertaken by the T1DAPC are described in other articles in this journal's issue.

PubMed Disclaimer

Conflict of interest statement

M.D.B. receives research support from Viacyte and Dexcom and is on the advisory board for Insulet. The other authors declare no conflict of interest.

Figures

FIGURE 1.
FIGURE 1.
NIDDK Strategic Plan for Research
FIGURE 2.
FIGURE 2.
Geographical location of the T1DAPC members.
FIGURE 3.
FIGURE 3.
Organization and governance of the T1DAPC.
See this image and copyright information in PMC

References

    1. Hart PA, Bellin MD, Andersen DK, et al. Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer. Lancet Gastroenterol Hepatol. 2016;1:226–237 - PMC - PubMed
    1. Peery AF, Crockett SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: Update 2018. Gastroenterology. 2019;156:254–272.e11. - PMC - PubMed
    1. Fagenholz PJ, Fernandez-del Castillo C, Harris NS, et al. Direct medical costs of acute pancreatitis hospitalizations in the United States. Pancreas. 2007;35:302–307. - PubMed
    1. Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nature reviews Gastroenterol Hepatol. 2019;16:479–496. - PubMed
    1. Yadav D, O’Connell M, Papachristou GI. Natural history following the first attack of acute pancreatitis. Am J Gastroenterol. 2012;107:1096–1103. - PubMed

Publication types