Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Cemal Yazici¹, Anne-Marie Dyer², Darwin L Conwell³, Elham Afghani⁴, Dana K Andersen⁵, Marina Basina⁶, Melena D Bellin, Leslie R Boone⁷, Anna Casu⁸, Jeffrey J Easler⁹, Carla J Greenbaum¹⁰, Phil A Hart³, Christie Y Jeon, Peter J Lee³, Shelby Meier⁷, Georgios I Papachristou³, Nazia T Raja-Khan¹¹, Zeb I Saeed¹², Jose Serrano⁵, Dhiraj Yadav¹³, Evan L Fogel⁹; Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)

Affiliations

¹ From the Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, IL.
² Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA.
³ Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH.
⁴ Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore.
⁵ Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD.
⁶ Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Palo Alto, CA.
⁷ Recruitment Innovation Center, Vanderbilt Institute for Clinical and Translational Research, Nashville, TN.
⁸ Translational Research Institute, AdventHealth, Orlando, FL.
⁹ Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN.
¹⁰ Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA.
¹¹ Division of Endocrinology, Diabetes and Metabolism, Penn State University College of Medicine, Hershey, PA.
¹² Division of Endocrinology, Indiana University School of Medicine, Indianapolis, IN.
¹³ Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA.

PMID: 36206465
PMCID: PMC9555856
DOI: 10.1097/MPA.0000000000002072

Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Cemal Yazici et al. Pancreas. 2022.

. 2022 Jul 1;51(6):598-603.

doi: 10.1097/MPA.0000000000002072.

Authors

Affiliations

¹ From the Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, IL.
² Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA.
³ Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH.
⁴ Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore.
⁵ Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD.
⁶ Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Palo Alto, CA.
⁷ Recruitment Innovation Center, Vanderbilt Institute for Clinical and Translational Research, Nashville, TN.
⁸ Translational Research Institute, AdventHealth, Orlando, FL.
⁹ Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN.
¹⁰ Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA.
¹¹ Division of Endocrinology, Diabetes and Metabolism, Penn State University College of Medicine, Hershey, PA.
¹² Division of Endocrinology, Indiana University School of Medicine, Indianapolis, IN.
¹³ Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA.

PMID: 36206465
PMCID: PMC9555856
DOI: 10.1097/MPA.0000000000002072

Abstract

Recruitment and retention of patients with acute pancreatitis (AP) in clinical studies can be challenging. While some obstacles are similar to other clinical conditions, some are unique to AP. Identifying potential barriers early and developing targeted solutions can help optimize recruitment and retention in AP studies. Such pre-emptive and detailed planning can help prospective, longitudinal studies focus on exocrine and endocrine complications of AP in accurately measuring outcomes. This article highlights the challenges in recruitment and retention strategies in AP studies and reviews available resources to create opportunities to address them. We describe the multifaceted approach used by the Recruitment and Retention Committee of the Type 1 Diabetes in Acute Pancreatitis Consortium, which builds upon earlier experiences to develop a recruitment and retention plan for the DREAM (Diabetes RElated to Acute pancreatitis and its Mechanisms) study.

Copyright © 2022 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.

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Conflict of interest statement

E.A. is part of advisory board for Nestle. M.D.B. receives research support from Viacyte and Dexcom and is part of advisory board for Insulet. AC is part of advisory board for GSK and expert opinion for Guidepoint. P.J.L. is part of advisory board for AbbVie. G.I.P. receives research support from AbbVie, has consulting activities with Olympus and Nestle, and receives equity with Ariel Precision Medicine. The other authors declare no conflict of interest.

Figures

**FIGURE 1.**
Schematic presentation of the T1DAPC Recruitment and Retention Committee that includes representatives from each of the T1DAPC clinical centers, DCC, and NIDDK. Structure of the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) Recruitment and Retention Committee

**FIGURE 2.**
The Recruitment Innovation Center (RIC) consultation involves engaging multidisciplinary RIC team in recruitment and retention planning and results in development of innovative solutions (obtained with permission from Wilkins et al). Schematic overview of Recruitment Innovation Center consultation process

See this image and copyright information in PMC

References

1. Krishna SG, Kamboj AK, Hart PA, et al. The changing epidemiology of acute pancreatitis hospitalizations: a decade of trends and the impact of chronic pancreatitis. Pancreas. 2017;46:482–488. - PMC - PubMed
1. Das SL, Singh PP, Phillips AR, et al. Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis. Gut. 2014;63:818–831. - PubMed
1. Shen HN, Yang CC, Chang YH, et al. Risk of diabetes mellitus after first-attack acute pancreatitis: A national population-based study. Am J Gastroenterol. 2015;110:1698–1706. - PubMed
1. Zhi M, Zhu X, Lugea A, et al. Incidence of new onset diabetes mellitus secondary to acute pancreatitis: A systematic review and meta-analysis. Front Physiol. 2019;10:637. - PMC - PubMed
1. Carlisle B, Kimmelman J, Ramsay T, et al. Unsuccessful trial accrual and human subjects protections: an empirical analysis of recently closed trials. Clin Trials. 2015;12:77–83. - PMC - PubMed

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Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Affiliations

Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding