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Comment
. 2022 Oct 6;29(10):1421-1423.
doi: 10.1016/j.stem.2022.09.007.

Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination

Ira Phadke  1 , Alka Dwivedi  2 , Naomi Taylor  3
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Free article
Comment

Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination

Ira Phadke et al. Cell Stem Cell. .
Free article

Abstract

Fibrosis, the pathological end stage of chronic inflammatory diseases, results from extracellular matrix deposition by fibrogenic fibroblasts. In this issue of Cell Stem Cell, Sobecki et al. (2022) develop a novel vaccination-based immunotherapy against fibrogenic progenitor-restricted antigens, leading to the regression of fibrosis in concert with liver and lung regeneration.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Vaccination-based immunotherapy to target profibrotic cells in liver and lung.
    Sobecki M, Chen J, Krzywinska E, Nagarajan S, Fan Z, Nelius E, Monné Rodriguez JM, Seehusen F, Hussein A, Moschini G, Hajam EY, Kiran R, Gotthardt D, Debbache J, Badoual C, Sato T, Isagawa T, Takeda N, Tanchot C, Tartour E, Weber A, Werner S, Loffing J, Sommer L, Sexl V, Münz C, Feghali-Bostwick C, Pachera E, Distler O, Snedeker J, Jamora C, Stockmann C. Sobecki M, et al. Cell Stem Cell. 2022 Oct 6;29(10):1459-1474.e9. doi: 10.1016/j.stem.2022.08.012. Epub 2022 Sep 15. Cell Stem Cell. 2022. PMID: 36113462

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