Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures
- PMID: 36206728
- DOI: 10.1016/j.stem.2022.09.004
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures
Abstract
Three recent studies from the Zernicka-Goetz and Hanna groups (Amadei et al., 2022; Tarazi et al., 2022; Lau et al., 2022) report the development of mouse embryo-like structures from stem cells. Using a combination of stem cell-derived sources, they show that mouse embryo-like structures develop key features mimicking post-gastrulation embryos.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests H.N. is an advisory board member of Cell Stem Cell.
Comment on
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Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.Cell. 2022 Sep 1;185(18):3290-3306.e25. doi: 10.1016/j.cell.2022.07.028. Epub 2022 Aug 1. Cell. 2022. PMID: 35988542 Free PMC article.
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Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development.Cell Stem Cell. 2022 Oct 6;29(10):1445-1458.e8. doi: 10.1016/j.stem.2022.08.013. Epub 2022 Sep 8. Cell Stem Cell. 2022. PMID: 36084657 Free PMC article.
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