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Review
. 2022 Dec 6;34(12):1906-1913.
doi: 10.1016/j.cmet.2022.09.013. Epub 2022 Oct 6.

Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program

Suzanne N Shapira  1 , Ali Naji  2 , Mark A Atkinson  3 , Alvin C Powers  4 , Klaus H Kaestner  5
Affiliations
Review

Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program

Suzanne N Shapira et al. Cell Metab. .

Abstract

In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community.

Keywords: T2D; epigenomics; islets; pancreas; type 2 diabetes.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.
HPAP Workflow
Figure 2.
Figure 2.
Programs connected to HPAP/PANC-DB
See this image and copyright information in PMC

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