Editorial

. 2022 Oct;42(7):1354-1359.

doi: 10.1007/s10875-022-01372-9. Epub 2022 Oct 8.

Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis

Alexandre Bolze¹, Trine H Mogensen^{2

3}, Shen-Ying Zhang^{4

5

6}, Laurent Abel^{4

5

6}, Evangelos Andreakos⁷, Lisa M Arkin⁸, Alessandro Borghesi⁹, Petter Brodin¹⁰, David Hagin¹¹, Giuseppe Novelli¹², Satoshi Okada¹³, Jonny Peter¹⁴, Laurent Renia^{15

16}, Karine Severe¹⁷, Pierre Tiberghien^{18

19}, Donald C Vinh^{20

21}; COVID human genetic effort; Elizabeth T Cirulli²², Jean-Laurent Casanova^{4

5

6

23

24}, Elena W Y Hsieh^{25

26}

Collaborators, Affiliations

Collaborators

COVID human genetic effort:
Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S Anderson, Andrés A Arias, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M Biggs, Dusan Bogunovic, Ahmed A Bousfiha, Manish J Butte, John Christodoulou, Aurelie Cobat, Roger Colobran, Antonio Condino-Neto, Stefan N Constantinescu, Clifton L Dalgard, Xavier Duval, Philippine Eloy, Sara Espinosa-Padilla, Jacques Fellay, Carlos Flores, José Luis Franco, Antoine Froidure, Guy Gorochov, Peter K Gregersen, Filomeen Haerynck, Rabih Halwani, Lennart Hammarström, Yuval Itan, Emmanuelle Jouanguy, Timokratis Karamitros, Yu-Lung Lau, Davood Mansouri, France Mentre, Isabelle Meyts, Kristina Mironska, Tomohiro Morio, Lisa F P Ng, Antonio Novelli, Cliona O'Farrelly, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarström, Rebeca Perez de Diego, Jordi Perez-Tur, David S Perlin, Graziano Pesole, Anna M Planas, Carolina Prando, Aurora Pujol, Lluis Quintana-Murci, Igor Resnick, Carlos Rodríguez-Gallego, Vanessa Sancho-Shimizu, Anna Sediva, Mikko R J Seppänen, Mohammed Shahrooei, Anna Shcherbina, Ondrej Slaby, Pere Soler-Palacín, Vassili Soumelis, András N Spaan, Ivan Tancevski, Stuart G Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Sophie Trouillet-Assant, Stuart E Turvey, KMFurkan Uddin, Diederik van de Beek, Horst von Bernuth, Qian Zhang

Affiliations

¹ Helix, San Mateo, CA, USA. alexandre.bolze@gmail.com.
² Department of Biomedicine, Aarhus University, Aarhus, Denmark.
³ Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
⁴ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
⁵ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
⁶ Université Paris Cité, Imagine Institute, Paris, France.
⁷ Laboratory of Immunobiology, Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
⁸ Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
⁹ Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
¹⁰ SciLifeLab, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
¹¹ Allergy and Clinical Immunology Unit, Department of Medicine, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel-Aviv, Tel-Aviv, Israel.
¹² Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133, Rome, Italy.
¹³ Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
¹⁴ Department of Medicine, Division of Allergy and Clinical Immunology, University of Cape Town, Cape Town, South Africa.
¹⁵ A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research, Singapore, Singapore.
¹⁶ Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore, Singapore.
¹⁷ Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.
¹⁸ Etablissement Francais du Sang, La Plaine-St Denis, France.
¹⁹ UMR 1098 RIGHT, Inserm EFS, Université de Franche-Comté, Besançon, France.
²⁰ Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.
²¹ Infectious Disease Susceptibility Program, Research Institute, McGill University Health Centre, Montréal, Québec, Canada.
²² Helix, San Mateo, CA, USA.
²³ Department of Pediatrics, Necker Hospital for Sick Children, Paris, France.
²⁴ Howard Hughes Medical Institute, New York, NY, USA.
²⁵ Department of Pediatrics, Section of Allergy and Immunology, University of Colorado Anschutz Medical Campus, School of Medicine, Children's Hospital Colorado, Aurora, CO, USA.
²⁶ Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

PMID: 36207567
PMCID: PMC9546418
DOI: 10.1007/s10875-022-01372-9

Editorial

Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis

Alexandre Bolze et al. J Clin Immunol. 2022 Oct.

. 2022 Oct;42(7):1354-1359.

doi: 10.1007/s10875-022-01372-9. Epub 2022 Oct 8.

Authors

Collaborators

COVID human genetic effort:
Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S Anderson, Andrés A Arias, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M Biggs, Dusan Bogunovic, Ahmed A Bousfiha, Manish J Butte, John Christodoulou, Aurelie Cobat, Roger Colobran, Antonio Condino-Neto, Stefan N Constantinescu, Clifton L Dalgard, Xavier Duval, Philippine Eloy, Sara Espinosa-Padilla, Jacques Fellay, Carlos Flores, José Luis Franco, Antoine Froidure, Guy Gorochov, Peter K Gregersen, Filomeen Haerynck, Rabih Halwani, Lennart Hammarström, Yuval Itan, Emmanuelle Jouanguy, Timokratis Karamitros, Yu-Lung Lau, Davood Mansouri, France Mentre, Isabelle Meyts, Kristina Mironska, Tomohiro Morio, Lisa F P Ng, Antonio Novelli, Cliona O'Farrelly, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarström, Rebeca Perez de Diego, Jordi Perez-Tur, David S Perlin, Graziano Pesole, Anna M Planas, Carolina Prando, Aurora Pujol, Lluis Quintana-Murci, Igor Resnick, Carlos Rodríguez-Gallego, Vanessa Sancho-Shimizu, Anna Sediva, Mikko R J Seppänen, Mohammed Shahrooei, Anna Shcherbina, Ondrej Slaby, Pere Soler-Palacín, Vassili Soumelis, András N Spaan, Ivan Tancevski, Stuart G Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Sophie Trouillet-Assant, Stuart E Turvey, KMFurkan Uddin, Diederik van de Beek, Horst von Bernuth, Qian Zhang

Affiliations

¹ Helix, San Mateo, CA, USA. alexandre.bolze@gmail.com.
² Department of Biomedicine, Aarhus University, Aarhus, Denmark.
³ Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
⁴ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
⁵ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
⁶ Université Paris Cité, Imagine Institute, Paris, France.
⁷ Laboratory of Immunobiology, Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
⁸ Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
⁹ Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
¹⁰ SciLifeLab, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
¹¹ Allergy and Clinical Immunology Unit, Department of Medicine, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel-Aviv, Tel-Aviv, Israel.
¹² Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133, Rome, Italy.
¹³ Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
¹⁴ Department of Medicine, Division of Allergy and Clinical Immunology, University of Cape Town, Cape Town, South Africa.
¹⁵ A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research, Singapore, Singapore.
¹⁶ Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore, Singapore.
¹⁷ Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.
¹⁸ Etablissement Francais du Sang, La Plaine-St Denis, France.
¹⁹ UMR 1098 RIGHT, Inserm EFS, Université de Franche-Comté, Besançon, France.
²⁰ Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.
²¹ Infectious Disease Susceptibility Program, Research Institute, McGill University Health Centre, Montréal, Québec, Canada.
²² Helix, San Mateo, CA, USA.
²³ Department of Pediatrics, Necker Hospital for Sick Children, Paris, France.
²⁴ Howard Hughes Medical Institute, New York, NY, USA.
²⁵ Department of Pediatrics, Section of Allergy and Immunology, University of Colorado Anschutz Medical Campus, School of Medicine, Children's Hospital Colorado, Aurora, CO, USA.
²⁶ Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

PMID: 36207567
PMCID: PMC9546418
DOI: 10.1007/s10875-022-01372-9

No abstract available

PubMed Disclaimer

Conflict of interest statement

A. Bolze and E.T.C. are employees of Helix. The other authors declare no competing interests.

Figures

**Fig. 1**
Decoding the human genetic and immunological basis of COVID-19 mRNA vaccine-induced myocarditis. Left panel: examples of germline genetic variants conferring a predisposition to adverse events following a spectrum of immunological triggers. Right panel: schematic diagram of the two main genetic analyses that will be performed. Cases are patients with COVID-19 mRNA vaccine-induced myocarditis. Created with BioRender.com

See this image and copyright information in PMC

References

1. Pöyhönen L, Bustamante J, Casanova J-L, Jouanguy E, Zhang Q. Life-threatening infections due to live-attenuated vaccines: early manifestations of inborn errors of immunity. J Clin Immunol. 2019;39:376–390. doi: 10.1007/s10875-019-00642-3. - DOI - PMC - PubMed
1. Gothe F, Howarth S, Duncan CJ, Hambleton S. Monogenic susceptibility to live viral vaccines. Curr Opin Immunol. 2021;72:167–175. doi: 10.1016/j.coi.2021.05.006. - DOI - PMC - PubMed
1. Tenforde MW, Self WH, Gaglani M, Ginde AA, Douin DJ, Talbot HK, et al. Effectiveness of mRNA vaccination in preventing COVID-19-associated invasive mechanical ventilation and death - United States, March 2021-January 2022. MMWR Morb Mortal Wkly Rep. 2022;71:459–465. doi: 10.15585/mmwr.mm7112e1. - DOI - PMC - PubMed
1. Rosenblum HG, Gee J, Liu R, Marquez PL, Zhang B, Strid P, et al. Safety of mRNA vaccines administered during the initial 6 months of the US COVID-19 vaccination programme: an observational study of reports to the Vaccine Adverse Event Reporting System and v-safe. Lancet Infect Dis. 2022;802–12. Available from: 10.1016/s1473-3099(22)00054-8. - PMC - PubMed
1. Nishibayashi H, Kishimoto S, Sekiguchi K, Okada S, Ihara K. Myocarditis in 13-year-old monochorionic diamniotic twins after COVID-19 vaccination. J Clin Immunol. 2022. Available from: 10.1007/s10875-022-01360-z. - PMC - PubMed

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Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis

Collaborators

Affiliations

Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis

Authors

Collaborators

Affiliations

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical