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Case Reports
. 2023 Aug;27(4):1203-1216.
doi: 10.1007/s11325-022-02718-8. Epub 2022 Oct 7.

Oral microbiota in obstructive sleep apnea patients: a systematic review

Giorgio Bianchi  1   2 , Nicola de'Angelis  1   3 , Paschalis Gavriilidis  4 , Iradj Sobhani  5   6 , Gian Luigi de'Angelis  7 , Maria Clotilde Carra  8
Affiliations
Case Reports

Oral microbiota in obstructive sleep apnea patients: a systematic review

Giorgio Bianchi et al. Sleep Breath. 2023 Aug.

Abstract

Purpose: Evidence suggests that patients with obstructive sleep apnea (OSA) are at increased risk of suffering from periodontitis, a chronic inflammatory disease of the tooth-supporting tissues associated with a dysbiotic oral microbiota. This systematic review aims to explore the current literature about the composition of the oral microbiota in patients with OSA compared to those without OSA.

Methods: Medline, Embase, and Cochrane Library were searched in May 2022 to identify original articles investigating the oral microbiota composition and/or oral microbiome (any microbiological technique) of patients with OSA (adults or children) vs. controls. Case report, reviews, and animal studies were excluded.

Results: Of over 279 articles initially identified, 8 were selected, of which 3 dealt with pediatric patients. Overall, 344 patients with OSA and 131 controls were included. Five studies used salivary samples, 2 oral mucosal swabs, and 1 subgingival plaque sample. With different methods to characterize oral microbiota, 6/8 studies observed significant differences between patients with OSA patients and controls in the composition and relative abundance of several bacteria species/genera linked to periodontitis.

Conclusion: Within the limitations of the available literature, the present systematic review indicates that OSA and related conditions (e.g., mouth breathing) are associated with different oral microbiota compositions, which may underlie the association between OSA and periodontitis.

Keywords: Obstructive sleep apnea; Oral microbiota; Systematic review.

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References

    1. Stazic P, Roguljic M, Dogas Z, Lusic Kalcina L, Pavlinac Dodig I, Valic M et al (2022) Periodontitis severity in obstructive sleep apnea patients. Clin Oral Investig. 26:407–415. https://doi.org/10.1007/s00784-021-04012-5 - DOI - PubMed
    1. Al-Jewair TS, Al-Jasser R, Almas K (2015) Periodontitis and obstructive sleep apnea’s bidirectional relationship: a systematic review and meta-analysis. Sleep Breath 19:1111–1120. https://doi.org/10.1007/s11325-015-1160-8 - DOI - PubMed
    1. Lembo D, Caroccia F, Lopes C, Moscagiuri F, Sinjari B, D’Attilio M (2021) Obstructive sleep apnea and periodontal disease: a systematic review. Medicina (Kaunas) 57. https://doi.org/10.3390/medicina57060640
    1. Sanders AE, Essick GK, Beck JD, Cai J, Beaver S, Finlayson TL et al (2015) Periodontitis and sleep disordered breathing in the Hispanic community health study/study of Latinos. Sleep 38:1195–1203. https://doi.org/10.5665/sleep.4890 - DOI - PubMed - PMC
    1. Al-Jewair T, Apessos I, Stellrecht E, Koch R, Almaghrabi B (2020) An update on the association between periodontitis and obstructive sleep apnea. Curr Oral Health Rep 7:189–201. https://doi.org/10.1007/s40496-020-00271-5 - DOI

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