Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Apr;123(2):739-741.
doi: 10.1007/s13760-022-02110-z. Epub 2022 Oct 7.

Adult-onset leukoencephalopathy with axonal spheroids and pigmental glia with diffuse cerebral microbleeds: case report

Affiliations
Case Reports

Adult-onset leukoencephalopathy with axonal spheroids and pigmental glia with diffuse cerebral microbleeds: case report

Ryo Ishikawa et al. Acta Neurol Belg. 2023 Apr.
No abstract available

Keywords: Adult-onset leukoencephalopathy with axonal spheroids and pigmental glia (ALSP); Cerebral microbleeds; Colony-stimulating factor 1 receptor; MRI; Young-onset dementia.

PubMed Disclaimer

References

    1. Rademakers R, Baker M, Nicholson AM, Rutherford NJ, Finch N, Soto-Ortolaza A, Lash J, Wider C, Wojtas A, DeJesus-Hernandez M, Adamson J, Kouri N, Sundal C, Shuster EA, Aasly J, MacKenzie J, Roeber S, Kretzschmar HA, Boeve BF, Knopman DS, Petersen RC, Cairns NJ, Ghetti B, Spina S, Garbern J, Tselis AC, Uitti R, Das P, Van Gerpen JA, Meschia JF, Levy S, Broderick DF, Graff-Radford N, Ross OA, Miller BB, Swerdlow RH, Dickson DW, Wszolek ZK (2012) Mutations in the colony timulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nat Genet 44:200–205 - DOI
    1. Konno T, Yoshida K, Mizuno T, Kawarai T, Tada M, Nozaki H, Ikeda SI, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T (2017) Clinical and genetic characterization of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF1R mutation. Eur J Neurol 24:37–45 - DOI - PubMed
    1. Mickeviciute GC, Valiuskyte M, Plattén M, Wszolek ZK, Andersen O, Danylaité Karrenbauer V, Ineichen BV, Granberg T (2021) Neuroimaging phenotypes of CSF1R-related leukoencephalopathy: systematic review, meta-analysis, and imaging recommendations. J Intern Med. https://doi.org/10.1111/joim.13420 - DOI - PubMed
    1. Zhuang LP, Liu CY, Li YX, Huang HP, Zou ZY (2020) Clinical features and genetic characteristics of hereditary diffuse leukoencephalopathy with spheroids due to CSF1R mutation: a case report and literature review. Ann Transl Med 8:11. https://doi.org/10.21037/atm.2019.12.17 - DOI - PubMed - PMC
    1. Bender B, Klose U, Lindig T, Biskup S, Nägele T, Schöls L, Karle KN (2014) Imaging features in conventional MRI, spectroscopy and diffusion weighted images of hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS). J Neurol 261:2351–2359 - DOI - PubMed

LinkOut - more resources