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. 2023 Feb;18(2):158-168.
doi: 10.1016/j.jtho.2022.09.220. Epub 2022 Oct 5.

Potential Impact of Criteria Modifications on Race and Sex Disparities in Eligibility for Lung Cancer Screening

Matthew P Smeltzer  1 , Wei Liao  2 , Nicholas R Faris  2 , Carrie Fehnel  2 , Jordan Goss  2 , Catherine J Shepherd  2 , Rodolfo Ramos  2 , Talat Qureshi  2 , Ayesha Mukhopadhyay  1 , Meredith A Ray  1 , Raymond Uyiosa Osarogiagbon  3
Affiliations
Free article

Potential Impact of Criteria Modifications on Race and Sex Disparities in Eligibility for Lung Cancer Screening

Matthew P Smeltzer et al. J Thorac Oncol. 2023 Feb.
Free article

Abstract

Introduction: Low-dose computed tomography (LDCT) screening reduces lung cancer mortality, but current eligibility criteria underestimate risk in women and racial minorities. We evaluated the impact of screening criteria modifications on LDCT eligibility and lung cancer detection.

Methods: Using data from a Lung Nodule Program, we compared persons eligible for LDCT by the following: U.S. Preventive Services Task Force (USPSTF) 2013 criteria (55-80 y, ≥30 pack-years of smoking, and ≤15 y since cessation); USPSTF2021 criteria (50-80 y, ≥20 pack-years of smoking, and ≤15 y since cessation); quit duration expanded to less than or equal to 25 years (USPSTF2021-QD25); reducing the pack-years of smoking to more than or equal to 10 years (USPSTF2021-PY10); and both (USPSTF2021-QD25-PY10). We compare across groups using the chi-square test or analysis of variance.

Results: The 17,421 individuals analyzed were of 56% female sex, 69% white, 28% black; 13% met USPSTF2013 criteria; 17% USPSTF2021; 18% USPSTF2021-QD25; 19% USPSTF2021-PY10; and 21% USPSTF2021-QD25-PY10. Additional eligible individuals by USPSTF2021 (n = 682) and USPSTF2021-QD25-PY10 (n = 1402) were 27% and 29% black, both significantly higher than USPSTF2013 (17%, p < 0.0001). These additional eligible individuals were 55% (USPSTF2021) and 55% (USPSTF2021-QD25-PY10) of female sex, compared with 48% by USPSTF2013 (p < 0.05). Of 1243 persons (7.1%) with lung cancer, 22% were screening eligible by USPSTF13. USPSTF2021-QD25-PY10 increased the total number of persons with lung cancer by 37%. These additional individuals with lung cancer were of 57% female sex (versus 48% with USPSTF2013, p = 0.0476) and 24% black (versus 20% with USPSTF2013, p = 0.3367).

Conclusions: Expansion of LDCT screening eligibility criteria to allow longer quit duration and fewer pack-years of exposure enriches the screening-eligible population for women and black persons.

Keywords: Disparities; Eligibility; LDCT; Lung cancer screening.

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