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Comment
. 2022 Oct 8;7(1):360.
doi: 10.1038/s41392-022-01205-6.

Targeting metabolic rewiring might decrease spread of tumor cells: Mitochondrial tRNA modifications promote cancer metastasis

Maik Luu  1 , Alexander Visekruna  2
Affiliations
Comment

Targeting metabolic rewiring might decrease spread of tumor cells: Mitochondrial tRNA modifications promote cancer metastasis

Maik Luu et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Mitochondrial tRNA modifications are involved in development of metastases by regulating metabolic plasticity of invasive tumor cells. Due to shortage of oxygen and nutrients in the tumor microenvironment of primary tumors, the tumor cells utilize glycolysis instead of OXPHOS for their energy supply. The metabolic switch from glycolysis to OXPHOS occurs when invasive tumor cells leave the primary tumors and settle in a new area (secondary tumors). Specific mitochondrial tRNA modifications such as m5C and f5C are introduced by the tRNA-modifying enzymes NSUN3 and ALKBH1, respectively. These modifications are essential for optimal protein synthesis of enzymes involved in mitochondrial respiration. In mice bearing neck or head tumors, depletion or pharmacological inhibition of NSUN3 leads to reduction of m5C in mitochondrial tRNA, resulting in decreased metastases in both lymph nodes and lungs. Similar effects on metastases can be achieved by using mitochondria-specific antibiotics
See this image and copyright information in PMC

Comment on

  • Mitochondrial RNA modifications shape metabolic plasticity in metastasis.
    Delaunay S, Pascual G, Feng B, Klann K, Behm M, Hotz-Wagenblatt A, Richter K, Zaoui K, Herpel E, Münch C, Dietmann S, Hess J, Benitah SA, Frye M. Delaunay S, et al. Nature. 2022 Jul;607(7919):593-603. doi: 10.1038/s41586-022-04898-5. Epub 2022 Jun 29. Nature. 2022. PMID: 35768510 Free PMC article.

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