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. 2022 Oct 8;74(1):74.
doi: 10.1186/s43044-022-00312-7.

Atrial depolarization abnormalities in pulmonary sarcoidosis

Amal Paul  1   2 , Akhil Paul  3 , Immanuel Subhash  3 , Bijesh Yadav  4 , John Roshan Jacob  5 , D J Christopher  3 , T Balamugesh  3
Affiliations

Atrial depolarization abnormalities in pulmonary sarcoidosis

Amal Paul et al. Egypt Heart J. .

Abstract

Background: Cardiac sarcoidosis, often manifested as sudden death, can be the first manifestation of sarcoidosis. Since 12-lead electrocardiogram (ECG) is recommended as an initial screening tool for cardiac sarcoidosis, the recognition of subtle abnormalities assumes utmost significance. The objective of this study was to identify the electrocardiographic abnormalities in patients with pulmonary sarcoidosis.

Results: A detailed analysis of 12-lead ECGs obtained from sixty patients with histopathologically proven pulmonary sarcoidosis and no overt cardiac involvement was done. The findings were compared with those of an age-matched control group. Varying degrees of intraventricular conduction defects were common in the study group [67%], as well as the control group [57%] [P = 0.23]. There was a higher prevalence of biphasic P wave [P = 0.003] and bifid P wave [P = 0.029] in lead III and rsr' in lead aVF [P = 0.03] in the study group as compared to the control group.

Conclusions: Our study demonstrates a greater prevalence of subtle ECG abnormalities in patients with pulmonary sarcoidosis as compared to patients with other forms of pulmonary disease. Atrial depolarization abnormalities were commoner in patients with pulmonary sarcoidosis.

Keywords: Atrial depolarization; Biphasic P; Cardiac sarcoidosis; Electrocardiogram (ECG); Sarcoidosis.

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Conflict of interest statement

The authors declare that we have no competing interests.

Figures

Fig. 1
Fig. 1
Typical biphasic P waves in lead III
Fig. 2
Fig. 2
Salient findings in leads II,III,aVF
See this image and copyright information in PMC

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