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. 2023 Jan 2:323:198953.
doi: 10.1016/j.virusres.2022.198953. Epub 2022 Oct 7.

Clinical study on the efficacy of hepatitis B vaccination in hepatitis C virus related chronic liver diseases in Egypt

Alshymaa A Hassnine  1 , Mona A Saber  2 , Yasser M Fouad  3 , Hatem Sarhan  2 , Mahmoud Ma Elsayed  4 , Zaki M Zaki  5 , Ehab M Abdelraheem  3 , Safaa M Abdelhalim  3 , Amr M Elsayed  3
Affiliations

Clinical study on the efficacy of hepatitis B vaccination in hepatitis C virus related chronic liver diseases in Egypt

Alshymaa A Hassnine et al. Virus Res. .

Abstract

Background: Chronic hepatitis B (HBV) and C virus (HCV) infections represent significant public health issues internationally. HBV vaccination has high sero-conversion rates in patients with mild to moderate chronic liver disease but has reduced efficacy in advanced stages.

Aim: to evaluate the efficacy of hepatitis B vaccination in HCV-related chronic liver disease and identify possible factors that may contribute to hypo-responsiveness in those patients.

Methods: Our study was a retrospective observational clinical study carried out at the tropical medicine department. It was conducted on 500 individuals (400 chronic HCV patients and 100 healthy controls). Individuals were divided into 5 groups: A (control group), B (cirrhotic patient not receiving treatment), C (chronic hepatitis patients receiving treatment), D (cirrhotic patients receiving treatment), and E (HCC patients receiving treatment). All individuals were subjected for comprehensive history taking, clinical examination, laboratory investigations, and assessment of anti-HBs titer.

Results: There is an inverse relationship between the level of anti-HBs Abs and the duration of vaccine. Diabetes and presence of cirrhosis have statistically significant relationship with serum anti-HBs Abs titer (P = 0.007). Oral DAAs therapy is associated with reduced response to HBV vaccine (only 31.75% of the patients were protected).

Conclusion: HCV infection and its complications significantly impair HBV vaccine response. Levels of anti-HBs Abs decline progressively with increasing duration from the last dose in immunization schedule of HBV vaccine. Diabetes and presence of cirrhosis being the main risk factors for vaccine hypo-responsiveness, also oral DAAs therapy is associated with reduced response to HBV vaccine.

Keywords: Chronic hepatitis B; DAAs; HCV; Liver cirrhosis; Vaccine response.

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Conflict of interest statement

Declaration of Competing Interests All authors declare no Conflict of interest

Figures

Fig 1
Fig. 1
Percentage of protected individuals vs. non-protected individuals in each studied group.
Fig 2
Fig. 2
Relation between serum anti-HBs Abs titer vs. the duration of HBV vaccination for all studied individuals.
See this image and copyright information in PMC

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