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. 2022 Sep;173(5):636-640.
doi: 10.1007/s10517-022-05603-2. Epub 2022 Oct 10.

Effect of Glycodelin on the Cytokine Profile of Rats during Allogeneic Bone Marrow Cell Transplantation

M S Bochkova  1   2 , V P Timganova  3 , K Yu Shardina  3 , S V Uzhviyuk  3 , N P Loginova  4 , Ya N Troinich  4 , S A Zamorina  3   5
Affiliations

Effect of Glycodelin on the Cytokine Profile of Rats during Allogeneic Bone Marrow Cell Transplantation

M S Bochkova et al. Bull Exp Biol Med. 2022 Sep.

Abstract

The protein glycodelin (PP14, PAEP) is associated with pregnancy and exhibits pronounced immunotropic properties. We studied the effect of glycodelin on the cytokine profile of blood serum during transplantation a suspension of allogeneic red bone marrow cells to Wistar rats. Recombinant glycodelin was administered to the animals 4 times (14 μg each time). Against the background of bone marrow cell transplantation, the levels of proinflammatory (IL-1α, IL-1β, and IL-18) and regulatory (IL-7, IL-12) cytokines and CSF (M-CSF) increased in blood serum, which indicates a systemic inflammatory response to the allograft. Glycodelin administration against the background of bone marrow cell allotransplantation led to a significant decrease in the proinflammatory cytokine IL-17A on day 21 of the experiment; the concentrations of the other cytokines remained unchanged. In general, glycodelin can suppress the level of IL-17A, a marker of graft rejection, which opens perspectives for its further investigation as a potential drug.

Keywords: Wistar rats; allogeneic transplant; cytokine profile; glycodelin.

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