Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 18;76(4):734-737.
doi: 10.1093/cid/ciac818.

Nasal and Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Levels Are Associated With Timing of Symptom Resolution in the ACTIV-2 Trial of Nonhospitalized Adults With Coronavirus Disease 2019

Yijia Li  1 , Linda J Harrison  2 , Kara W Chew  3 , Judy S Currier  3 , David A Wohl  4 , Eric S Daar  5 , Teresa H Evering  6 , Ryan Wu  2 , Mark Giganti  2 , Justin Ritz  2 , Arzhang Cyrus Javan  7 , Robert W Coombs  8 , Carlee Moser  2 , Michael D Hughes  2 , Joseph J Eron  4 , Davey M Smith  9 , Jonathan Z Li  1
Affiliations

Nasal and Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Levels Are Associated With Timing of Symptom Resolution in the ACTIV-2 Trial of Nonhospitalized Adults With Coronavirus Disease 2019

Yijia Li et al. Clin Infect Dis. .

Abstract

Acute Coronavirus Disease 2019 symptoms limit daily activities, but little is known about its association with severe acute respiratory syndrome coronavirus 2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we showed that high anterior nasal RNA levels and detectable plasma RNA were associated with delayed symptom improvement. Clinical Trials Registration. https://clinicaltrials.gov/ct2/show/NCT04518410.

Keywords: COVID-19; RNA; SARS-CoV-2; symptom duration.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest. L. J. H.: reports grants or contracts from NIH/NIAID 3 UM1 AI068636-16S1 and NIH/NIAID T32 AI007358 (paid to institution). K. W. C.: research funding to the institution from Merck, Sharp & Dohme (paid to institution) and Amgen (research contract with institution), consultant for Pardes Biosciences, honoraria to the author for CME presentations (not-for-profit organization) from International Antiviral Society–USA, participation on a Data Safety Monitoring Board or Advisory Board for University of California, San Francisco (UCSF) (served as Chair of a Safety Monitoring Committee for an investigator-initiated study where the sponsor is UCSF). E. S. D.: receives consulting fees from Gilead Sciences, Merck, and GSK/ViiV and research support through the institution from Gilead Sciences and GSK/ViiV and reports support from NIH, including participation on a Data Safety Monitoring Board or Advisory Board for Gilead and ViiV. D. A. W. has received funding to the institution to support research and honoraria for advisory boards and consulting from Gilead Sciences and grant or contracts from Lilly. J. Z. L. has consulted for AbbVie and received a research grant from Merck. J. J. E. is an ad hoc consultant to GSK/Vir Biotechnology and is data monitoring committee (DMC) chair for Adagio phase III studies. J. S. C. has consulted for Merck and Company and reports a leadership or fiduciary role in other board, society, committee, or advocacy groups as a volunteer for the Board of Directors International Antiviral Society–USA and the Foundation Board, Conference on Retroviruses and Opportunistic Infections. D. M. S. has consulted for Bayer Healthcare, Fluxergy, Kiadis, Linear Therapies, Matrix BioMed, VxBiosciences, Model Medicines, Bayer Pharmaceuticals, and Pharma Holdings; has grants or contracts from NIH (DK131532, AI169609, DA047039, AI036214, AI131385, AI100665, AI126620: funding provided to institution), The James B. Pendleton Charitable Trust, and The James B. Pendleton Charitable Trust John and Mary Tu Foundation, including payment or honoraria for lectures, presentations, speaker’s bureaus, manuscript writing, or educational events for Medscape (COVID treatment), American Institute Continuing Medical Education (COVID treatment), and Kiadis; stock or stock options for Model Medicine, Linear Therapies, and Cv Biosciences; and receipt of equipment, materials, drugs, medical writings, gifts, or other services from The James B. Pendleton Charitable Trust. T. H. E. receives consulting fees from Tonix Pharmaceuticals. C. M. reports participation on a Data Safety Monitoring Board for BONE START. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

Associated data