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Review
. 2022 Sep 23:13:971156.
doi: 10.3389/fimmu.2022.971156. eCollection 2022.

Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation

Jiaqi Cui  1 , Kui Zhao  1 , Yanling Sun  1 , Ruijuan Wen  1 , Xiangzhong Zhang  1 , Xudong Li  1 , Bing Long  1
Affiliations
Review

Diagnosis and treatment for the early stage of cytomegalovirus infection during hematopoietic stem cell transplantation

Jiaqi Cui et al. Front Immunol. .

Abstract

Cytomegalovirus (CMV) infection remains a frequent complication after hematopoietic stem cell transplantation (HSCT) and causes significant morbidity and mortality in transplantation recipients. In this review, we highlight the role of major risk factors that are associated with the incidence of CMV infection. Advances in immunosurveillance may predict CMV infection, allowing early interventions to prevent severe infection. Furthermore, numerous therapeutic strategies against CMV infection after HSCT are summarized. A comprehensive understanding of the current situation of CMV treatment may provide a hint for clinical practice and even promote the development of novel strategies for precision medicine.

Keywords: CMV; HSCT; diagnosis; immune recovery; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Immune recovery in the early stage after CMV infection during HSCT. During the first 100 days after HSCT, NK and T cells play a crucial role in controlling CMV infection. Matured NK cells directly lyse CMV infected cells or indirectly facilitate Th1 responses to control CMV infection. T cells also exert their cytotoxic function through both existing and newly generated populations.
See this image and copyright information in PMC

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