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Review
. 2022 Sep 23:13:1025872.
doi: 10.3389/fimmu.2022.1025872. eCollection 2022.

Effect of stereotactic radiotherapy on immune microenvironment of lung cancer

Yao Xiao  1 , Hongqing Zhuang  1
Affiliations
Review

Effect of stereotactic radiotherapy on immune microenvironment of lung cancer

Yao Xiao et al. Front Immunol. .

Abstract

Stereotactic radiotherapy (SRT) is one of the main treatment modalities for lung cancer, and the current SRT approach combined with immunotherapy has initially presented good clinical efficacy in lung cancer. SRT activates the immune system through in situ immunization, releasing antigens into the blood, which promotes the antigen-antibody response and then induces tumor cell apoptosis. Dose fractionation has different effects on the immune microenvironment, and the tumor microenvironment after SRT also changes over time, all of which have an impact on SRT combined immunotherapy. Although much research on the immune microenvironment of SRT has been conducted, many problems still require further exploration.

Keywords: SBRT; hypofractionated radiotherapy (HFRT); immune microenvironment; immunotherapy; lung cancer; stereotactic radiotherapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of anti-tumor humoral immunity after SBRT. After SBRT, many tumor-associated antigen (TAA) fragments are released into the blood and stimulate the differentiation of B lymphocytes into plasma cells. Furthermore, plasma cells produce antibodies and bind to tumor cells to form antigen–antibody complexes, and are then phagocytosed and cleared by macrophages.
See this image and copyright information in PMC

References

    1. Lubas MJ, Kumar SS. The combined use of sbrt and immunotherapy-a literature review. Curr Oncol Rep (2020) 22(12):117. doi: 10.1007/s11912-020-00986-9 - DOI - PubMed
    1. Wang Z, Wei L, Li J, Zhou H, Li S, Chen D, et al. . Combing stereotactic body radiotherapy with checkpoint inhibitors after oligoprogression in advanced non-small cell lung cancer. Transl Lung Cancer Res (2021) 10(12):4368–79. doi: 10.21037/tlcr-21-682 - DOI - PMC - PubMed
    1. Akanda ZZ, Neeson PJ, John T, Barnett S, Hanna GG, Miller A, et al. . A narrative review of combined stereotactic ablative radiotherapy and immunotherapy in metastatic non-small cell lung cancer. Transl Lung Cancer Res (2021) 10(6):2766–78. doi: 10.21037/tlcr-20-1117 - DOI - PMC - PubMed
    1. Bestvina CM, Pointer KB, Karrison T, Al-Hallaq H, Hoffman PC, Jelinek MJ, et al. . A phase 1 trial of concurrent or sequential ipilimumab, nivolumab, and stereotactic body radiotherapy in patients with stage iv nsclc study. J Thorac Oncol (2022) 17(1):130–40. doi: 10.1016/j.jtho.2021.08.019 - DOI - PubMed
    1. Zhou P, Chen D, Zhu B, Chen W, Xie Q, Wang Y, et al. . Stereotactic body radiotherapy is effective in modifying the tumor genome and tumor immune microenvironment in non-small cell lung cancer or lung metastatic carcinoma. Front Immunol (2021) 11:594212. doi: 10.3389/fimmu.2020.594212 - DOI - PMC - PubMed

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