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Case Reports
. 2022 Sep 17:43:101068.
doi: 10.1016/j.gore.2022.101068. eCollection 2022 Oct.

Pure ovarian dysgerminoma in a postmenopausal patient: A case report and review of the management

Jennifer Vaz  1 , Alexandra Mulliken  1 , Nivin Omar  2 , Jessa Suhner  1 , Bogna Brzezinska  1 , Thomas Cotter  2 , Patel Nikhil  2 , Robert V Higgins  1 , Bunja Rungruang  1
Affiliations
Case Reports

Pure ovarian dysgerminoma in a postmenopausal patient: A case report and review of the management

Jennifer Vaz et al. Gynecol Oncol Rep. .

Abstract

Background: A pure ovarian dysgerminoma in a postmenopausal female is a rare phenomenon.

Case: A 65-year-old female presented with a large pelvic mass. Following surgical debulking, the patient was diagnosed with FIGO Stage IIB ovarian dysgerminoma. She was treated with three cycles of etoposide and cisplatin and has been disease-free for 12 months.

Conclusion: Dysgerminomas in postmenopausal females are uncommon. Gynecologic oncologists should be familiar with the pathological diagnosis and treatment recommendations to achieve optimal outcomes.

Keywords: Germ cell tumor; Ovarian germ cell tumor; Pure ovarian dysgerminoma.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Radiology and Pathology Findings (A–I). Preoperative radiographic image of CT abdomen/pelvis showing a bulky lobulated mass arising from the pelvis and extending cephalad to the umbilical level (1A), gross image of 19.5 cm tan-yellow lobulated mass encompassing left ovary (1B), cross section of tumor showing areas of hemorrhage and abundant necrosis (1C), hematoxylin and eosin (H&E) at low power shows nests of large, uniform polygonal cells with pale cytoplasm and distinct cell membrane with brisk mitosis, and extensive necrosis (1D), H&E at high power showing tumor cells separated by fibrous septate in an alveolar pattern containing lymphocytes, plasma cells, and eosinophils (1E), H&E at low power shows metastasis in peritoneum (1F1) and posterior cul-de-sac (1F2), IHC staining of tumor cells show strong membranous staining with CD117 (1G) and strong nuclear staining with SALL4 (1H), and OCT3/4 (1I).
See this image and copyright information in PMC

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