Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Apr-Jun;18(2):225-227.
doi: 10.4183/aeb.2022.225.

PARATHYROID ADENOMA MIMICKING TUBERCULOSIS IN A PERITONEAL DIALYSIS PATIENT

Affiliations
Case Reports

PARATHYROID ADENOMA MIMICKING TUBERCULOSIS IN A PERITONEAL DIALYSIS PATIENT

S Karahisar Şirali et al. Acta Endocrinol (Buchar). 2022 Apr-Jun.

Abstract

The most common cause of hypercalcemia is parathyroid hyperplasia and carcinoma. Tuberculosis(TB) and sarcoidosis are the most common granulomatous diseases of the parathyroid. We report a case of parathyroid adenoma that can mimic many lesions. A 46-year-old woman on continuous ambulatory peritoneal dialysis (CAPD) with symptoms and signs of hypercalcemia. Laboratory findings were consistent with tertiary hyperparathyroidism. She underwent elective parathyroidectomy due to high PTH values despite effective treatment including calcimimetics and vitamin D receptor activators. Subtotal thyroidectomy and three and a half of parathyroid adenomas were removed. Histopathological examination revealed features of parathyroid adenoma with granulomatosis infection that supports tuberculosis. In order to confirm the pathological findings, the PCR study was performed on the pathology specimens. After obtaining a negative result, the treatment was stopped. We have reported a case of parathyroid adenoma that mimicking tuberculosis.

Keywords: granulomatous inflammation; hyperparathyroidism; tuberculosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Scintigraphic view of the involvement of pathological activity in the patient’s nodular lesions.
Figure 2
Figure 2
Histopathologic findings of the patient pointing out Langhans type giant cells and epithelioid histiocytes.

References

    1. Silverberg SJ, Bilezikian JP. Evaluation and management of primary hyperparathyroidism. J Clin Endocrinol Metab. 1996;81:2036–2040. - PubMed
    1. Plaza LR, Ramia A, Arteaga P, Garcia A, Lopez M, Mediana V, Gonzales S, Manuel V, Latorre F. Eur Arch Otorhinolryngol. 2018;275(3):659–669. - PubMed
    1. Hewison M, Burke F, Evans KN, Lammas DA, Sansom DM, Liu P, Modlin RL, Adams JS. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol. 2007;103(3-5):316–321. - PubMed
    1. Anaforoglu I, Siviloğlu C, Livaoğlu A, Algun E. Granulomatous infiltration of a paratyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report. J Med Case Reports. 2010;4:400. - PMC - PubMed
    1. Sadideen HM, Blaker P, Donnell PO, Taylor J, Goldsmith DJ. Tuberculosis complicating tertiary hyperparathyroidism in a patient with end-stage renal disease. A case report. J Nephrol. 2008;21:438–441. - PubMed

Publication types

LinkOut - more resources