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. 2022 Sep 21:12:847400.
doi: 10.3389/fonc.2022.847400. eCollection 2022.

A pilot study of cognitive behavioural therapy integrated with activity pacing for fatigued breast cancer patients undergoing chemotherapy in Ethiopia

Mikiyas Amare Getu  1   2   3 , Changying Chen  1   2 , Adamu Addissie  4   5 , Edom Seife  6 , Panpan Wang  7 , Eva Johanna Kantelhardt  4   8
Affiliations

A pilot study of cognitive behavioural therapy integrated with activity pacing for fatigued breast cancer patients undergoing chemotherapy in Ethiopia

Mikiyas Amare Getu et al. Front Oncol. .

Abstract

Background: Fatigue is a common symptom in breast cancer patients, and it is one of the major factors that influence the quality of life (QoL). Cognitive behavioural therapy (CBT) has been recommended to manage cancer-related fatigue. In this study, CBT will be integrated with activity pacing (AP), which can help breast cancer patients achieve a balance between activity and rest. Therefore, this pilot study aimed to investigate the acceptability, feasibility, and efficacy of the CBT-AP intervention.

Methods: A total of 10 fatigued breast cancer patients undergoing chemotherapy were included in the study. The acceptability and feasibility of the study were measured by the patient recruitment rate, attrition rate, intervention fidelity, intervention compliance, and therapist's and participant's evaluations of the intervention. The outcomes were measured at baseline and at 6 weeks of intervention.

Results: The pre-post study suggested that CBT-AP was found to be acceptable and feasible for fatigued breast cancer patients undergoing chemotherapy. Among 27 eligible participants, 10 (37.03%) participants accepted our invitation to participate in the study. One participant dropped out from the intervention because of serious illness, and the dropout rate was 10%.Both the intervention fidelity and intervention compliance were found to be satisfactory.Fatigue severity [Brief Fatigue Inventory (BFI)] was reduced in 77.77% of participants from baseline to 6 weeks of intervention. The global health status/QoL scale and physical, emotional, and social functioning scales were improved from baseline to 6 weeks of intervention. All symptom scales, except constipation, diarrhea, and financial difficulties, were decreased after the intervention. Depression [Public Health Questionnaire (PHQ)-9] was reduced in 55.55% of participants.

Conclusion: This study suggested that CBT-AP is an acceptable, feasible, and potentially efficacious intervention to reduce fatigue and improve the QoL of breast cancer patients. The efficacy of a CBT-AP programme is going to be investigated in subsequent larger randomized clinical trials.

Keywords: breast cancer; cognitive behavioural therapy; depression; fatigue; pilot study; quality of life.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Cognitive behavioural therapy integrated with activity pacing (CBT-AP) patient recruitment CONSORT diagram.
Figure 2
Figure 2
Estimated mean trajectories of fatigue and depression among breast cancer patients.
Figure 3
Figure 3
Estimated mean trajectories of quality of life functioning scores among breast cancer patients.
Figure 4
Figure 4
Estimated mean trajectories of quality of life symptom scores among breast cancer patients.
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References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. . Global cancer statistics 2020 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin (2021) 71(3):209–49. doi: 10.3322/caac.21660 - DOI - PubMed
    1. American cancer society Breast cancer facts and figures 2019-2020. Atlanta: American Cancer Society; (2019).
    1. Campbell KL, Pusic AL, Zucker DS, McNeely ML, Binkley JM. A prospective model of care for breast cancer rehabilitation: Function. Cancer (2012) 118(8 suppl):2300–11. doi: 10.1002/cncr.27464 - DOI - PubMed
    1. Zaidi S, Hussain S, Verma S, Veqar Z, Khan A, Nazir SU, et al. . Efficacy of complementary therapies in the quality of life of breast cancer survivors. Front Oncol (2018) 7. doi: 10.1097/SMJ.0b013e3181c38c41 - DOI - PMC - PubMed
    1. Mohammed A, Taye G, Gizaw M, Hussien M. Quality of life and associated factors among patients with breast cancer under chemotherapy at tikur anbessa specialized hospital, Addis Ababa, Ethiopia. PloS One (2019) 14(9):1–13. doi: 10.1371/journal.pone.0222629 - DOI - PMC - PubMed

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