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Review
. 2022 Sep 21:13:1000454.
doi: 10.3389/fneur.2022.1000454. eCollection 2022.

Made to measure-Selecting outcomes in aneurysmal subarachnoid hemorrhage research

Christopher R Andersen  1   2   3 , Shane W English  4   5 , Anthony Delaney  1   2   3
Affiliations
Review

Made to measure-Selecting outcomes in aneurysmal subarachnoid hemorrhage research

Christopher R Andersen et al. Front Neurol. .

Abstract

There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current process for determining "what" to measure in aSAH and identify some of the shortcomings of these approaches. A consideration of the unique clinical course of aSAH is then discussed and how this impacts on selecting the best timepoints to assess change in the chosen constructs. We also review the how to critically appraise different measurement instruments and some of the issues with how these are applied in the context of aSAH. We conclude with current initiatives to improve outcome selection in aSAH and future directions in the research agenda.

Keywords: core outcome set (COS); measurement instruments; outcome assessment (health care); patient reported outcome measures; stroke; subarachnoid hemorrhage.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Three step process for selecting outcome measures in aSAH, starting with the domain of interest, the timepoint and then measurement instrument.
Figure 2
Figure 2
Classification of some of the common outcome domains used in aSAH research based on the OMERACT filter 2.0 (10).
See this image and copyright information in PMC

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