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Review
. 2022 Sep 30:2022:1720749.
doi: 10.1155/2022/1720749. eCollection 2022.

Efficacy and Safety of Wuling Powder in the Treatment of Patients with Diabetic Nephropathy: A Systematic Review and Meta-Analysis

Yunyi Yang  1 , Wenjun Sha  1 , Keke Hou  1 , Yuanying Xu  1 , Shufa Tan  2 , Hongping Yin  1 , Lin Chen  1   3 , Tao Lei  1
Affiliations
Review

Efficacy and Safety of Wuling Powder in the Treatment of Patients with Diabetic Nephropathy: A Systematic Review and Meta-Analysis

Yunyi Yang et al. Evid Based Complement Alternat Med. .

Abstract

Background: Wuling powder is a classical formula of traditional Chinese medicine (TCM), which is extensively applied to treat diabetic nephropathy (DN). However, there are no related reports on systematically evaluating the efficacy of Wuling powder in the treatment of DN. Targeted at this, this study was developed.

Materials and methods: This study systematically searched related articles from nine databases, including PubMed, Cochrane Library, Embase, Web of Science, China Knowledge Infrastructure (CNKI), China Biomedical CD-ROM (Sino Med), Wanfang database, Vipers database (VIP), and the China Clinical Trials Registry website. The randomized controlled trials (RCTs) involving Wuling Power to treat DN were included, which were published from the established data of the above databases to March 2022. In addition, the language of the studies was not restricted. Studies were meta-analyzed using the RevMan 5.4 software given in the Cochrane Collaboration Network. The treatment efficacy was measured using the weighted mean differences (WMD) and 95% confidence intervals (CI).

Results: 24 studies were included for the final analysis. 24 h urine volume (WMD = 357.95; 95% CI [322.83, 393.06], p < 0.00001), 24 h urine protein quantification(24 h UPQ) (WMD = -1.30; 95% CI [-1.82, -0.78], p < 0.00001), serum creatinine (Scr) (WMD = -10.17; 95% CI [-11.13, -9.21], p < 0.00001), blood urea nitrogen (BUN) (WMD = -1.62; 95% CI [-2.30, -0.93], p < 0.00001), urinary albumin excretion rate (UAER) (WMD = -24.73; 95% CI [-35.46, -13.99], p < 0.00001), fasting blood glucose (FBG) (WMD = -0.63.95% CI [-0.97, -0.30], p = 0.002), glycated hemoglobin (WMD = -0.11; 95% CI [-0.30, 0.08], p=0.26), total cholesterol (TC) (WMD = -0.63; 95% CI [-1.23, -0.04], p=0.04), triglycerides (TG) (WMD = -0.46. 95% CI [-0.70, -0.23], p=0.0001), high-density lipoprotein cholesterol (HDL-C) (WMD = -0.32; 95% CI [0.03, 0.62], p=0.03), low-density lipoprotein cholesterol (LDL-C) (WMD = -0.57; 95% CI [-0.77, -0.37], p < 0.00001), and total effective rate (TER) (response ratio (RR) = 1.40; 95% CI [1.32, 1.48]; p < 0.00001) were concluded. The Wuling powder in the treatment of DN was statistically significant in all the above outcome indicators, and the efficacy of the treatment group was better than that of the control group.

Conclusion: The results of this study provided evidence for the clinical application of Wuling powder to treat the DN, but it had to be further validated in higher-quality clinical studies.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of the paper.

Figures

Figure 1
Figure 1
Compositions of Wuling powder.
Figure 2
Figure 2
Flowchart of specific publications screening.
Figure 3
Figure 3
Risk of bias.
Figure 4
Figure 4
Summary chart of risk of bias.
Figure 5
Figure 5
Forest plot of 24 h urine volume.
Figure 6
Figure 6
Forest plot for 24 h UPQ.
Figure 7
Figure 7
Forest plot of Scr.
Figure 8
Figure 8
Forest plot of BUN.
Figure 9
Figure 9
Forest plot of UAER.
Figure 10
Figure 10
Forest plot of FBG.
Figure 11
Figure 11
Forest plot of glycated hemoglobin.
Figure 12
Figure 12
Forest plot of TC.
Figure 13
Figure 13
Forest plot of TG.
Figure 14
Figure 14
Forest plot of HDL.
Figure 15
Figure 15
Forest plot of LDL.
Figure 16
Figure 16
Forest plot of TER.
Figure 17
Figure 17
The publication bias funnel chart of 24 h urine volume.
Figure 18
Figure 18
The publication bias funnel chart of 24 h UPQ.
Figure 19
Figure 19
The publication bias funnel chart of Scr.
Figure 20
Figure 20
The publication bias funnel chart of BUN.
Figure 21
Figure 21
The publication bias funnel chart of UAER.
Figure 22
Figure 22
The publication bias funnel chart of FBG.
Figure 23
Figure 23
The publication bias funnel chart of glycated hemoglobin.
Figure 24
Figure 24
The publication bias funnel chart of TC.
Figure 25
Figure 25
The publication bias funnel chart of TG.
Figure 26
Figure 26
The publication bias funnel chart of HDL-C.
Figure 27
Figure 27
The publication bias funnel chart of LDL-C.
Figure 28
Figure 28
The publication bias funnel chart of TER.
See this image and copyright information in PMC

References

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