Fine-structural changes of synapses in the superior cervical ganglion of adult rats after long-term administration of GABA. A morphometric analysis
- PMID: 3621301
- DOI: 10.1007/BF00215509
Fine-structural changes of synapses in the superior cervical ganglion of adult rats after long-term administration of GABA. A morphometric analysis
Abstract
The superior cervical ganglion (SCG) of adult rats was exposed to gamma-aminobutyric acid (GABA) by means of long-term microapplication. Serial sections were cut from GABA-treated and control ganglia, and subsequently the fine structure of individual synapses was investigated. The quantitative analysis of structural parameters of studied synapses showed that significant changes consisting of (1) a reduction in size of presynaptic axon terminals, (2) a decrease in the number of synaptic vesicles, and (3) a diminution in the extent of the postsynaptic membrane thickening at the dendritic side developed as an effect of GABA-treatment. These results provide morphological evidence that long-term application of GABA to the SCG exerts a combination of effects on both presynaptic and postsynaptic elements. It is suggested that the structural changes observed in the fine structure of individual synapses within the SCG may play an integral role in the development of the synaptogenetic action of GABA.
Similar articles
-
Modulation by GABA of neuroplasticity in the central and peripheral nervous system.Neurochem Res. 1993 Apr;18(4):453-61. doi: 10.1007/BF00967249. Neurochem Res. 1993. PMID: 8474568 Review.
-
Induction and maintenance of free postsynaptic membrane thickenings in the adult superior cervical ganglion.J Neurocytol. 1979 Oct;8(5):549-63. doi: 10.1007/BF01208509. J Neurocytol. 1979. PMID: 553147
-
Termination pattern and fine structural characteristics of GABA- and [Met]enkephalin-containing nerve fibers and synapses in the superior cervical ganglion of adult rat.Neuroscience. 1992 Aug;49(4):963-71. doi: 10.1016/0306-4522(92)90372-9. Neuroscience. 1992. PMID: 1436490
-
Fine structural changes in the superior cervical ganglion of adult rats after long-term administration of baclofen, a GABAB receptor agonist.Neuroscience. 1990;36(1):239-45. doi: 10.1016/0306-4522(90)90365-b. Neuroscience. 1990. PMID: 2215920
-
Morphology of synapses in the autonomic nervous system.J Electron Microsc Tech. 1988 Oct;10(2):187-204. doi: 10.1002/jemt.1060100205. J Electron Microsc Tech. 1988. PMID: 3068334 Review.
Cited by
-
In situ GABAergic modulation of synchronous gonadotropin releasing hormone-1 neuronal activity.J Neurosci. 2002 Oct 15;22(20):8932-41. doi: 10.1523/JNEUROSCI.22-20-08932.2002. J Neurosci. 2002. PMID: 12388600 Free PMC article.
-
Ultrastructural changes in the juxtamembranous layer of ganglionar neurons with orthodromic pessimal stimulation.Neurosci Behav Physiol. 1991 Mar-Apr;21(2):110-6. doi: 10.1007/BF01182884. Neurosci Behav Physiol. 1991. PMID: 1715057 No abstract available.
-
Modulation by GABA of neuroplasticity in the central and peripheral nervous system.Neurochem Res. 1993 Apr;18(4):453-61. doi: 10.1007/BF00967249. Neurochem Res. 1993. PMID: 8474568 Review.
-
Ganglionic Long-Term Potentiation in Prehypertensive and Hypertensive Stages of Spontaneously Hypertensive Rats Depends on GABA Modulation.Neural Plast. 2019 Oct 13;2019:7437894. doi: 10.1155/2019/7437894. eCollection 2019. Neural Plast. 2019. PMID: 31737063 Free PMC article.
-
A novel sympathetic neuronal GABAergic signalling system regulates NE release to prevent ventricular arrhythmias after acute myocardial infarction.Acta Physiol (Oxf). 2019 Oct;227(2):e13315. doi: 10.1111/apha.13315. Epub 2019 Jun 12. Acta Physiol (Oxf). 2019. PMID: 31116911 Free PMC article.