Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;35(12):e15917.
doi: 10.1111/dth.15917. Epub 2022 Oct 17.

Topical cyclosporine hydrogel preparation: A new therapeutic option in the treatment of nail psoriasis

Giuseppe Gallo  1 , Luca Mastorino  1 , Diego Barilà  2 , Francesco Cattel  2 , Michele Panzone  1 , Pietro Quaglino  1 , Simone Ribero  1 , Paolo Dapavo  1
Affiliations

Topical cyclosporine hydrogel preparation: A new therapeutic option in the treatment of nail psoriasis

Giuseppe Gallo et al. Dermatol Ther. 2022 Dec.

Abstract

Nail psoriasis is a chronic nail disorder that commonly affects psoriatic patients causing severe distress despite the limited body surface area. Treatments for nail psoriasis are limited, as nails are often difficult to treat with topical therapies, and among different systemic agents responses are unpredictable. We carried out a prospective study in order to analyze the effectiveness and tolerability of topical cyclosporine hydrogel ointment in nail psoriasis. Three patients, for a total of 44 nails, were treated with topical cyclosporine hydrogel ointment. All nails were evaluated, before starting the treatment, every 28 days and after 12 weeks of therapy, by the same dermatologists, through clinical and onychoscopic evaluations. The patients were also asked to assess on the compliance with product use. Complete response (CR) was observed in 2 of 3 patients; a partial response (PR) was observed in the other patient. Overall, 24 of 44 nails had CR and 20 had a PR. Cyclosporine hydrogel ointment has shown efficacy and safety in the treatment of nail psoriasis. The product has also been shown to be stable in composition, easy to apply and not discomfortable for the patient.

Keywords: cyclosporine; hydrogel ointment; nail psoriasis; topical therapy; treatment.

PubMed Disclaimer

References

REFERENCES

    1. Rigopoulos D, Rompoti N, Gregoriou S. Management of nail psoriasis. Dermatol Clin. 2021;39(2):211-220. doi:10.1016/j.det.2020.12.014
    1. Belyayeva E, Gregoriou S, Chalikias J, et al. The impact of nail disorders on quality of life. Eur J Dermatol. 2013;23(3):366-371. doi:10.1684/ejd.2013.2048
    1. Balestri R, Rech G, Rossi E, et al. Natural history of isolated nail psoriasis and its role as a risk factor for the development of psoriatic arthritis: a single-centre cross-sectional study. Br J Dermatol. 2017;176(5):1394-1397. doi:10.1111/bjd.15026
    1. Rigopoulos D, Baran R, Chiheb S, et al. Recommendations for the definition, evaluation, and treatment of nail psoriasis in adult patients with no or mild skin psoriasis: a dermatologist and nail expert group consensus. J Am Acad Dermatol. 2019;81(1):228-240. doi:10.1016/j.jaad.2019.01.072
    1. Cannavò SP, Guarneri F, Vaccaro M, Borgia F, Guarneri B. Treatment of psoriatic nails with topical cyclosporin: a prospective, randomized placebo-controlled study. Dermatology. 2003;206(2):153-156. doi:10.1159/000068469

LinkOut - more resources