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. 2022 Nov:351:1003-1016.
doi: 10.1016/j.jconrel.2022.10.003. Epub 2022 Oct 13.

Preparation of particle-attached microneedles using a dry coating process

Jeong-Eun Choi  1 , Hye-Ran Cha  2 , Suwan Kim  1 , Ji Seok Kim  3 , Mun-Jin Kim  1 , Hyeon Woo Chung  2 , Seung-Ki Baek  3 , Jae Myun Lee  4 , Jung-Hwan Park  5
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Preparation of particle-attached microneedles using a dry coating process

Jeong-Eun Choi et al. J Control Release. 2022 Nov.

Abstract

The standard process for manufacturing microneedles containing API requires a way to process the API, including dissolving the API in a co-solvent and a drying process. In this study, the authors introduce a novel microneedle system that involves physically attaching API particles to the biocompatible adhesive surface of the microneedles. To manufacture particle-attached microneedles, an adhesive surface was prepared by coating polydimethylsiloxane (PDMS) mixed with an elastomer base and a curing agent at a ratio of 40:1 (PDMS40) onto polylactic acid microneedles (PLA), and then attaching ovalbumin (OVA) particles with a mean diameter of 10 μm to the PDMS adhesive layer. The OVA particles were delivered for 5 min into porcine skin with a delivery efficiency of 93% ex vivo and into mouse skin with a delivery efficiency of over 90% in vivo. Finally, mouse experiments with OVA particle-attached microneedles showed a value of OVA antibody titer similar to that produced by intramuscular administration. Particle-attached microneedles are a novel microneedle system with a dry coating process and rapid API delivery into the skin. Particle-attached microneedles can provide a wide range of applications for administering drugs and vaccines.

Keywords: Dry coating; Particle-attached microneedles; Physical attachment; Polydimethylsiloxane; Rapid delivery.

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Conflict of interest statement

Declaration of Competing Interest Jung-Hwan Park is an inventor of patents that have been licensed to companies developing microneedle-based products, is a shareholder of companies developing microneedle-based products.

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