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Comment
. 2022 Dec;85(6):702-769.
doi: 10.1016/j.jinf.2022.09.029. Epub 2022 Oct 8.

CXCL16 associates with adverse outcome and cardiac involvement in hospitalized patients with Covid-19

Ida Gregersen  1 , Thor Ueland  2 , Jan Cato Holter  3 , Maria Belland Olsen  4 , Annika E Michelsen  5 , Sarah L Murphy  5 , Anders Aune Tveita  6 , Katerina Nezvalova Henriksen  7 , Hedda Hoel  8 , Lena Bugge Nordberg  9 , Aleksander Rygh Holten  10 , Thor Edvardsen  11 , Kuan Yang  4 , Lars Heggelund  12 , Marius Trøseid  13 , Fredrik Müller  3 , Anders Benjamin Kildal  14 , Anne Ma Dyrhol-Riise  15 , Andreas Barratt-Due  16 , Tuva B Dahl  17 , Pål Aukrust  13 , Bente Halvorsen  5 ; NOR-SOLIDARITY consortium, The Norwegian SARS-CoV-2 Study Group investigators
Affiliations
Comment

CXCL16 associates with adverse outcome and cardiac involvement in hospitalized patients with Covid-19

Ida Gregersen et al. J Infect. 2022 Dec.
No abstract available

Keywords: Chemokines; Heart; Infection; SARS-CoV-2; Severity.

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Conflict of interest statement

Declaration of Competing Interest JCH and AMDR has received funding from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; LH has stock ownership in Algipharma AS; ARH has received honoraria from Pfizer for lectures: TE is former (immediate past) President European Association of Cardiovascular Imaging. The other authors report no conflict of interest.

Figures

Fig 1
Fig. 1
Intra-hospital temporal profile of CXCL16 according to (A) ICU admission during the first 10 days after inclusion in the combined cohort and within cohorts. (B) CXCL16 and 60-day mortality in severe Covid-19. (C) Temporal profile of CXCL16 during the first 10 days after inclusion according to 60-day mortality. (D) Correlation plot between CXCL16 and NT-proBNP and (E) TnT during the first 10 days after inclusion. Blue circles are at admission, green circles at 3–5 days and red circles at 7–10 days. The correlation coefficients are Pearson. The p-values reflect the group (outcome) effect from the linear mixed models and the interaction p-value (group*time) is shown in italic if significant. gray areas reflect reference value range from age- and sex-matched healthy controls. *p < 0.05, **p < 0.01, ***p < 0.001 between groups. BL; baseline, RF; acute respiratory failure, ICU; intensive care unit; NT-proBNP; N-terminal-pro-B-type natriuretic peptide, Tnt; Troponin.
See this image and copyright information in PMC

Comment on

References

    1. Kim S.H., et al. Diagnostic value of serum KL-6 and IL-6 levels in critically ill patients with Covid-19-associated pneumonia. J Infect. 2022 - PMC - PubMed
    1. Ellinghaus D., et al. Genomewide association study of severe Covid-19 with respiratory failure. N Engl J Med. 2020;383(16):1522–1534. - PMC - PubMed
    1. Jansson A.M., et al. Soluble CXCL16 predicts long-term mortality in acute coronary syndromes. Circulation. 2009;119(25):3181–3188. - PubMed
    1. Schranz D., et al. Fatty acid-binding protein 3 and CXC-chemokine ligand 16 are associated with unfavorable outcome in aneurysmal subarachnoid hemorrhage. J Stroke Cerebrovasc Dis. 2021;30(11) - PubMed
    1. Villar J., et al. Clinical and biological markers for predicting ARDS and outcome in septic patients. Sci Rep. 2021;11(1):22702. - PMC - PubMed