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Case Reports
. 1987 Jun;31(6):413-5.
doi: 10.1111/j.1399-0004.1987.tb02835.x.

The Brachmann-de Lange syndrome in two siblings of normal parents

J P Fryns, A M Dereymaeker, M Hoefnagels, F D'Hondt, G Mertens, H van den Berghe
Case Reports

The Brachmann-de Lange syndrome in two siblings of normal parents

J P Fryns et al. Clin Genet. 1987 Jun.

Abstract

In this report we describe two male siblings with typical Brachmann-de Lange syndrome. Both presented a severe form of this MCA syndrome, and died at the age of 3 months and 3 weeks, respectively. Family history was completely negative, parents were normal, and prometaphase chromosome studies failed to reveal a chromosomal basis for this unique malformation syndrome.

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