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Comment
. 2022 Nov;43(11):861-863.
doi: 10.1016/j.it.2022.09.013. Epub 2022 Oct 7.

Cutting edge: interleukin-17a prompts HIF1α for wound healing

Minhal Ahmed  1 , Jun R Huh  2
Affiliations
Comment

Cutting edge: interleukin-17a prompts HIF1α for wound healing

Minhal Ahmed et al. Trends Immunol. 2022 Nov.

Abstract

IL-17a is widely considered an inflammatory cytokine, linked to the development and severity of autoimmune diseases such as inflammatory bowel disease and psoriasis. However, a recent report by Konieczny et al. sheds light on a novel protective role of IL-17a in wound healing, adding to the growing list of studies highlighting a noninflammatory function for IL-17a.

Keywords: HIF-1α; immunoepithelial; immunometabolism; interleukin-17a; wound healing; γδ T cells.

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Conflict of interest statement

Declaration of interests No interests are declared.

Comment on

  • Interleukin-17 governs hypoxic adaptation of injured epithelium.
    Konieczny P, Xing Y, Sidhu I, Subudhi I, Mansfield KP, Hsieh B, Biancur DE, Larsen SB, Cammer M, Li D, Landén NX, Loomis C, Heguy A, Tikhonova AN, Tsirigos A, Naik S. Konieczny P, et al. Science. 2022 Jul 8;377(6602):eabg9302. doi: 10.1126/science.abg9302. Epub 2022 Jul 8. Science. 2022. PMID: 35709248 Free PMC article.

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