Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Jan;67(1):182-90.

Expression of class II MHC antigens on alveolar epithelium in fibrosing alveolitis

C G Kallenberg, B M Schilizzi, F Beaumont, S Poppema, L De Leij, T H The

Expression of class II MHC antigens on alveolar epithelium in fibrosing alveolitis

C G Kallenberg et al. Clin Exp Immunol. 1987 Jan.

Abstract

Lung biopsy specimens from eight patients with fibrosing alveolitis with or without connective tissue disease were investigated for the presence of immune deposits and the expression of class II histocompatibility antigens on the alveolar epithelium. Immune deposits were not detected. The alveolar epithelium stained strongly with anti-Ia (HLA-DR) monoclonal antibodies in seven out of eight biopsy specimens from the patients, but not in control lung tissue. Sub- and intra-epithelially localized mononuclear cell infiltrates consisted predominantly of T8-positive (cytotoxic/suppressor) lymphocytes. The expression of class II antigens on the alveolar epithelium and its infiltration with T8 positive cells is consistent with local presentation of self-antigens and an ensuing local immune response.

PubMed Disclaimer

References

    1. Clin Immunol Immunopathol. 1978 Jul;10(3):270-7 - PubMed
    1. Clin Exp Immunol. 1979 Sep;37(3):381-90 - PubMed
    1. Kidney Int. 1980 Jan;17(1):1-13 - PubMed
    1. Am J Med. 1980 Aug;69(2):204-17 - PubMed
    1. J Immunol. 1980 Oct;125(4):1678-85 - PubMed

LinkOut - more resources