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. 2022 Dec;40(Suppl 2):193-203.
doi: 10.1007/s40273-022-01192-0. Epub 2022 Oct 10.

A Value Set for the EQ-5D-Y-3L in the Netherlands

Bram Roudijk  1 , Ayesha Sajjad  2 , Brigitte Essers  3 , Stefan Lipman  2 , Peep Stalmeier  4 , Aureliano Paolo Finch  5
Affiliations

A Value Set for the EQ-5D-Y-3L in the Netherlands

Bram Roudijk et al. Pharmacoeconomics. 2022 Dec.

Abstract

Background and objective: There is increasing interest in preference-accompanied measures of health for paediatric populations. The child-friendly EQ-5D version, EQ-5D-Y-3L, is one such instrument, but the lack of a Dutch value set prevents its use in economic evaluations of healthcare interventions in the Netherlands. This study aims at covering this gap by collecting preferences using a standardised protocol for deriving EQ-5D-Y-3L value sets.

Methods: Composite time trade-off data were collected using videoconferencing interviews, with each respondent completing ten composite time trade-off tasks. Discrete choice experiment data were collected using an online survey, with respondents each completing 15 paired comparisons. Respondents completed these tasks considering what they prefer for a hypothetical 10-year-old child. Discrete choice experiment data were analysed using a ten-parameter mixed-logit model and anchored to the quality-adjusted life-year scale using the mean observed composite time trade-off values.

Results: The study collected preferences for 197 respondents using composite time trade-off and for 959 respondents using a discrete choice experiment. The discrete choice experiment sample was representative for the Dutch population in terms of age and sex. The level 3 weight for pain/discomfort was the largest, followed by feeling worried, sad or unhappy, usual activities, mobility and self-care. Health state values ranged between -0.218 and 1.

Conclusions: This study generated a Dutch value set for the EQ-5D-Y-3L, which can be used for the computation of quality-adjusted life-years for economic evaluations of healthcare interventions in paediatric populations.

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Conflict of interest statement

Bram Roudijk, Stefan Lipman, Peep Stalmeier and Aureliano Paolo Finch reported receiving grants from the EuroQol Research Foundation during the conduct of the study. Bram Roudijk, Peep Stalmeier and Aureliano Paolo Finch are members of the EuroQol Group. Ayesha Sajjad and Brigitte Essers report no conflict of interest.

Figures

Fig. 1
Fig. 1
Distribution of cTTO responses
Fig. 2
Fig. 2
Scatter plots for the predicted, rescaled DCE values and the mean observed cTTO values for the 28 health states included in the health state design, for all three anchoring strategies.
Fig. 3
Fig. 3
Values for all 243 health states, generated through either DCE (mixed logit model rescaled on the mean cTTO value for state 33333) or cTTO responses (heteroskedastic model without constant)
See this image and copyright information in PMC

References

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